Results 121 to 130 of about 1,147,765 (344)
Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Landscape Dynamics of the Mu Us Sandy Land Based on Multi-Source Remote Sensing Images
LandThis study meticulously investigates landscape alterations within the Mu Us Sandy Land, a critical region for desertification control in China. The research dissects the dynamic characteristics and inter-conversion of landscape elements across eleven ...
Bingqiang Fei +10 more
doaj +1 more source
Author Correction: Single compounds elicit complex behavioural responses in wild, free-ranging rats
Scientific Reports, 2018 A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Michael D. Jackson +2 more
doaj +1 more source
Chronic locked posterior gleno-humeral dislocation: technical note on fibular grafting for restoration of humeral head sphericity [PDF]
, 2021 Amr Abdel-Mordy Kandeel
openalex +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
On symmetry non-restoration at high temperature [PDF]
, 1996 Giuseppe Bimonte, G. Lozano
openalex +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Global Ecology and ConservationEstuaries are critical habitats for many marine species, but are also experiencing rapid human-induced environmental change, posing great challenges for conservation.
Yuke Zhang +6 more
doaj +1 more source