Results 101 to 110 of about 830,111 (315)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Local habitat restoration in streams: Constraints on the effectiveness of restoration for stream biota

, 2003
The restoration of physical habitat has emerged as a key activity for managers charged with reversing the damage done by humans to streams and rivers, and there has been a great expenditure of time, money and other resources on habitat restoration ...
Lake, P., Lake, PS, Bond, NR, Bond, N.
core   +1 more source

The Economics of Restoration [PDF]

, 2012
Macro-economic decisions determine the resources allocated at an international and a country-level to natural resource management. Micro-economic theory and tools are then used to ensure that this allocation will materialize into desired economic, environmental and societal outcomes. Restoration projects differ in their costs and benefits.
Wilson, Kerrie A., Lulow, Megan, Burger, Jutta, McBride, Marissa F.   +3 more
openaire   +4 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Amphiphilic Chitosan–PEI Hybrid Nanocarrier Enhances Delivery Efficiency and Immunogenicity of PEDV mRNA Vaccines

International Journal of Nanomedicine
Shangen Xu,1– 4 Haiwen Zhong,1 Linyun Li,1 Yao Chen,1 Chenxi Sun,1 Zhicheng Lao,1 Afei Wang,1 Tianyu Qian,1 Xiaohua Wang,1– 4 Kai Zhao1– 4 1Zhejiang Key Laboratory for Restoration of Damaged Coastal Ecosystems, School of Life Sciences, Taizhou University,
Xu S, Zhong H, Li L, Chen Y, Sun C, Lao Z, Wang A, Qian T, Wang X, Zhao K   +9 more
doaj  

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Integrating ecological and ethnobotanical priorities into riparian restoration

, 2010
The riparian vegetation along many rivers is so modified by farming and grazing that forest restoration targets are far from obvious, and initial steps are hard to plan.
Santana-Michel, F.J., F. J. Santana-Michel, A. E. Allen, Allen, A.E., C. O. Arrona, Arrona, C.O., Zedler, J.B., J. B. Zedler   +7 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Decoupling Distribution of n-Alkanes in Aeolian Sand and Vegetation of the Northern Ulan Buh Desert, China: Insight into Organic Matter Preservation in Arid Regions

Plants
Fallen leaves and their decomposition directly deposit leaf wax n-alkanes into sediments, which can be used to identify local flora. These n-alkanes are important for studying past vegetation and climate, but their distribution in sediments must be known.
Shangzhe Zhou, Lei Xi, Mengchun Cui, Guipeng Cui, Pan Gao, Jinlei Zhu, Weiyuan Kong, Yufu Jia, Qi Lu   +8 more
doaj   +1 more source