Results 121 to 130 of about 1,942,619 (360)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Early Warning and Risk Assessment for Rainfall-Induced Shallow Loess Landslides

open access: yesApplied Sciences
Rainfall-induced shallow loess landslides pose a significant threat to human life and property. Early warning and risk assessment of these landslides are critical prerequisites for engineering control and disaster loss reduction.
Feng Gao   +6 more
doaj   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

Assessment of recent eastern oyster (Crassostrea virginica) reef restoration projects in the Great Bay Estuary, New Hampshire: Planning for the future [PDF]

open access: yes, 2016
Current oyster populations in New Hampshire total less than 10% of what they were in the 1980s, and the causal factors for the declines include disease, sedimentation, and human harvest.
Grizzle, Raymond E., Ward, Krystin M.
core   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

PACO: Global Signal Restoration via PAtch COnsensus [PDF]

open access: green, 2018
Ignacio Francisco Ramírez Paulino
openalex   +1 more source

Cutting Down Damages Awards in Timber Trespass Cases [PDF]

open access: yes, 2016
The Alaska Supreme Court recently heard two cases addressing damages awards for timber trespass claims. Both cases, Wiersum v. Harder and Chung v. Park , emphasized the difficulty of obtaining restoration damages and the close scrutiny given to the size ...
Diehr, Dana M.
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

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