Results 81 to 90 of about 1,106,370 (306)

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

ROS homeostasis and cell wall biosynthesis pathway are involved in female inflorescence development of birch (Betula platyphylla)

BMC Plant Biology
Background Female inflorescence development from megasporogenesis to gametogenesis, and mature female gametophyte (FG), is a complex and important event in plant sexual reproduction. However, how this essential developmental process is regulated in birch
Mengjie Cai, Kehao Zeng, Lanlan Li, Jiayuan Shi, Bello Hassan Jakada, Xue Zhang, Pu Wang, Haonan Zhu, Jing Jiang, Xingguo Lan   +9 more
doaj   +1 more source

Restoring the Already Restored

, 2022
Restoration has been a tool for enhancing selected parts of history, which tells about the ideals of its time. Today most older buildings have already been through several restorations or renovations. How should one approach and valuate historical layers?
openaire   +1 more source

Restoring the Regulated: The EU's Nature Restoration Law

Journal of Environmental Law
Abstract To halt the decline of the natural environment, attention is increasingly directed towards nature restoration. A recent example of this is the EU’s Nature Restoration Law (NRL). This article presents an assessment of the NRL, arguing that the NRL is ambitious but that this ambition comes with a risk of it becoming a performative
Emma Lees, Ole W Pedersen
openaire   +2 more sources

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Decoding anthropogenic risk through historical baselines: a conservation prioritization framework for Chinese white dolphin in anthropogenic seascapes

Frontiers in Marine Science
Coastal cetaceans confront intensifying anthropogenic pressures, yet quantifying historical habitat loss remains methodologically challenging in data-scarce regions where shifting baseline syndrome obscures conservation targets.
Liming Yong, Liming Yong, Xixia Lu, Xixia Lu, Qianhui Zeng, Qianhui Zeng, Liyuan Zhao, Liyuan Zhao, Yuke Zhang, Yuke Zhang, Xianyan Wang, Xianyan Wang   +11 more
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Assessing acute thermal assays as a rapid screening tool for coral restoration

Scientific Reports
Escalating environmental threats to coral reefs coincides with global advancements in coral restoration programs. To improve long-term efficacy, practitioners must consider incorporating genotypes resilient to ocean warming and disease while maintaining ...
C. N. Klepac, C. G. Petrik, E. Karabelas, J. Owens, E. R. Hall, E. M. Muller   +5 more
doaj   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source