Results 71 to 80 of about 1,942,619 (360)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Hydrochemical Characteristics and Control Factors of Strontium Enrichment of Groundwater in the Eastern Sanjiang Plain, China

Journal of Chemistry
Strontium (Sr) is one of the essential trace elements in the human body, which has important biological significance for human physiological function. In this paper, 41 groundwater samples collected from Shengli Farm in the eastern Sanjiang Plain were ...
Jingjie Li, Mingguo Wang, Tao Yang, Sheng Lian, Huaisheng Zhang, Chao Bian, Xuqing Wang, Shixiong Tian   +7 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

COMPOSITE RESTORATIONS

International Journal of Advanced Research, 2019
Improvements in tooth-coloured restoratives and bonding technology have made dental procedures more palatable and feasible. Patients are attracted to a restoration that matches the color of natural teeth. Resin composites meet this demand and have become the most frequently used esthetic material in dentistry.
K. Lahari, Shipra Jaidka, Somani, Rani, Revelli, Ashok, Kumar, Dilip, Rishi Jaidka   +5 more
openaire   +1 more source

Optimal Algorithms for Near-Hitless Network Restoration via Diversity Coding

, 2012
Diversity coding is a network restoration technique which offers near-hitless restoration, while other state-of-the art techniques are significantly slower.
Avci, Serhat Nazim, Ayanoglu, Ender
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Restoration of missing lines in grip patterns for biometrics authentication on a smart gun [PDF]

, 2006
The Secure Grip project1 aims to develop a grip-pattern recognition system, as part of a smart gun. Its target users are the police officers. The current authentication algorithm is based on a likelihood-ratio classifier.
Ganzevoort, W.P.T., Kooi, K., Shang, X., Veldhuis, R.N.J.   +3 more
core   +2 more sources

The Universe as a Nonuniform Lattice in the Finite-Dimensional Hypercube II.Simple Cases of Symmetry Breakdown and Restoration [PDF]

, 2004
This paper continues a study of field theories specified for the nonuniform lattice in the finite-dimensional hypercube with the use of the earlier described deformation parameters.
A. E. SHALYT-MARGOLIN, Adler R. J., Ahluwalia D. V., Faddeev L., Feynman R. P., Garay L., Hassan S. F., Heisenberg W., Kempf A., Maggiore M., Maggiore M., Peskin M., Shalyt-Margolin A. E., Shalyt-Margolin A. E., Shalyt-Margolin A. E., Shalyt-Margolin A. E., Shalyt-Margolin A. E.   +16 more
core   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source