Results 91 to 100 of about 1,942,619 (360)

Assessing acute thermal assays as a rapid screening tool for coral restoration

Scientific Reports
Escalating environmental threats to coral reefs coincides with global advancements in coral restoration programs. To improve long-term efficacy, practitioners must consider incorporating genotypes resilient to ocean warming and disease while maintaining ...
C. N. Klepac, C. G. Petrik, E. Karabelas, J. Owens, E. R. Hall, E. M. Muller   +5 more
doaj   +1 more source

Decoding anthropogenic risk through historical baselines: a conservation prioritization framework for Chinese white dolphin in anthropogenic seascapes

Frontiers in Marine Science
Coastal cetaceans confront intensifying anthropogenic pressures, yet quantifying historical habitat loss remains methodologically challenging in data-scarce regions where shifting baseline syndrome obscures conservation targets.
Liming Yong, Liming Yong, Xixia Lu, Xixia Lu, Qianhui Zeng, Qianhui Zeng, Liyuan Zhao, Liyuan Zhao, Yuke Zhang, Yuke Zhang, Xianyan Wang, Xianyan Wang   +11 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Oyster Reef Restoration Project for the City of Dover, Grizzle [PDF]

, 2006
This project was conducted as a contract between the City of Dover and the University of New Hampshire, with additional funding supplied by the New Hampshire Estuaries Project.
Abeels, Holly, Greene, Jennifer, Grizzle, Raymond E.   +2 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Abandoned project restoration model (APRM) for residential construction projects [PDF]

, 2017
Incompletion of construction projects is a common phenomenon in Malaysia. Project abandonment has given an adverse consequences to the economy, society and environment. In the best interest of the end users and other parties involved in the contract, the
Doraisamy, Sanitha V.
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Amphiphilic Chitosan–PEI Hybrid Nanocarrier Enhances Delivery Efficiency and Immunogenicity of PEDV mRNA Vaccines

International Journal of Nanomedicine
Shangen Xu,1– 4 Haiwen Zhong,1 Linyun Li,1 Yao Chen,1 Chenxi Sun,1 Zhicheng Lao,1 Afei Wang,1 Tianyu Qian,1 Xiaohua Wang,1– 4 Kai Zhao1– 4 1Zhejiang Key Laboratory for Restoration of Damaged Coastal Ecosystems, School of Life Sciences, Taizhou University,
Xu S, Zhong H, Li L, Chen Y, Sun C, Lao Z, Wang A, Qian T, Wang X, Zhao K   +9 more
doaj  

Spare capacity modelling and its applications in survivable iP-over-optical networks [PDF]

, 2006
As the interest in IP-over-optical networks are becoming the preferred core network architecture, survivability has emerged as a major concern for network service providers; a result of the potentially huge traffic volumes that will be supported by ...
Al-Barrak, S., Harle, D.A.
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source