Results 31 to 40 of about 56,805 (219)

Study on Ecological Restoration Zoning of the Ebinur Lake Basin Based on the Evaluation of Ecological Function Importance and Ecosystem Sensitivity

Land
The Ebinur Lake Basin, a key ecological security barrier for windbreak and sand control in northern Xinjiang, is crucial to the ecological safety of western China and the northern sand-prevention belt.
Jiaxiu Zou, Yiming Feng, Lei Xi, Zhao Qi, Xiaoming Cao, Lili Wang   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Influence of Lime in Adobe Optimization Against Humidity [PDF]

مسکن و محیط روستا, 2018
The importance and the value of historical buildings and sites and even villages which have adobe houses causes that conservators annually schedule restoration plans and programs to protect the buildings from hazards. This is done because conservation of
kaveh Bahramzadeh, Alireza Razeghi, Najme Khatoon Miri   +2 more
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Extraction of Sparse Vegetation Cover in Deserts Based on UAV Remote Sensing

Remote Sensing
The unique characteristics of desert vegetation, such as different leaf morphology, discrete canopy structures, sparse and uneven distribution, etc., pose significant challenges for remote sensing-based estimation of fractional vegetation cover (FVC ...
Jie Han, Jinlei Zhu, Xiaoming Cao, Lei Xi, Zhao Qi, Yongxin Li, Xingyu Wang, Jiaxiu Zou   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Temporal changes in habitat structure and gastropod community assemblage in response to active restoration of a Central American mangrove

Frontiers in Marine Science
Mangrove forests are biodiversity hotspots that provide critical ecosystem services, from coastal protection to carbon storage. Yet, these ecosystems are disappearing at alarming rates, and while restoration efforts are expanding globally, long-term ...
Linda López-Abuchar, Christian Peralta-Madriz, Carolina Soto-Navarro, Gabriela Vinueza-Hidalgo, Andrew Whitworth, Christopher Beirne   +5 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source