Results 71 to 80 of about 96,125 (306)

A Satellite View of the Wetland Transformation Path and Associated Drivers in the Greater Bay Area of China during the Past Four Decades

Remote Sensing
As a highly productive and biologically diverse ecosystem, wetlands provide unique habitat for a wide array of plant and animal species. Owing to the strong disturbance by human activities and climate change, wetland degradation and fragmentation have ...
Kun Sun, Weiwei Yu
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Aesthetics of Restoration and Conservation

, 2022
It. Estetica della conservazione-restauro; Fr. Esthétique de la conservation-restauration; Germ. Ästhetik der Konservierung-Restaurierung; Sp. Estética de la Conservación-Restauración. The label refers to the philosophical and aesthetic debates surrounding the conservation and restoration of artworks, buildings, and other artefacts of cultural ...
openaire   +3 more sources

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Construction of a Desertification Composite Index and Its Application in the Spatiotemporal Analysis of Land Desertification in the Ring-Tarim Basin over 30 Years

Remote Sensing
Desertification is one of the most severe environmental issues facing the world today, and effective desertification monitoring is critical for understanding its dynamics and developing prevention and control strategies.
Lei Xi, Zhao Qi, Yiming Feng, Xiaoming Cao, Mengcun Cui, Jiaxiu Zou, Shiang Feng   +6 more
doaj   +1 more source

Recent Developments in Materials Science for the Conservation and Restoration of Historic Artifacts

Applied Sciences
The preservation of cultural heritage artifacts presents complex challenges that require innovative solutions to prevent deterioration and extend the lifespan of priceless historical objects. Advances in materials science are revolutionizing the field of
M. Doni, I. Fierăscu, R. Fierăscu
semanticscholar   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

A win-win strategy for ecological restoration and biodiversity conservation in Southern China

, 2017
Environmental degradation and poverty are linked, and must be tackled together. Doing so requires a win-win strategy that both restores the environment and ensures a sustainable livelihood for those who are affected by the restoration project.
Shixiong Cao, D. Shang, H. Yue, Hua Ma
semanticscholar   +1 more source

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source