Results 61 to 70 of about 96,125 (306)

Considering plant functional connectivity in landscape conservation and restoration management

Biodiversity and Conservation, 2022
Landscape connectivity has traditionally been studied for animal species rather than for plants, especially under a multispecies approach. However, connectivity can be equally critical for both fauna and flora and, thus, an essential point in the ...
Teresa Goicolea, Rubén G. Mateo, María José Aroca‐Fernández, A. Gastón, J. García‐Viñas, M. C. Mateo-Sánchez   +5 more
semanticscholar   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Temporal changes in habitat structure and gastropod community assemblage in response to active restoration of a Central American mangrove

Frontiers in Marine Science
Mangrove forests are biodiversity hotspots that provide critical ecosystem services, from coastal protection to carbon storage. Yet, these ecosystems are disappearing at alarming rates, and while restoration efforts are expanding globally, long-term ...
Linda López-Abuchar, Christian Peralta-Madriz, Carolina Soto-Navarro, Gabriela Vinueza-Hidalgo, Andrew Whitworth, Christopher Beirne   +5 more
doaj   +1 more source

The integration of 3D technology for the conservation and restoration of ruined archaeological artifacts

History of Sciences and Technology, 2022
The restoration and conservation of monuments and archaeological sites is a delicate operation. It requires fidelity, delicacy, precision and archaeological authenticity.
Sana Simou, K. Baba, A. Nounah
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

An Explanation of Design Principles of Illumination Systems in Historical Places [PDF]

صفه, 2019
Despite the more than half-a-century long history of scientific conservation and restoration of monuments in Iran, the lighting and illumination of monuments is still missing from the discipline’s curriculum, with few instances of appropriate lighting in
GholamReza Kiani Dehkiani, Marzieh Safari HassanAbadi   +1 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Dynamics of Logging in Solomon Islands: The Need for Restoration and Conservation Alternatives

, 2015
Forests of Asia-Pacific islands have undergone degradation by some of the worst-known selective logging practices in the tropics. It is unclear whether severely damaged forests can return to a pre-logging state via natural regeneration, or whether active
Eric Katovai, W. Edwards, W. Laurance
semanticscholar   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source