Results 181 to 190 of about 5,965,661 (287)

Impact of prehospital olanzapine for methamphetamine intoxication on patient and system-level outcomes: a population-based retrospective cohort study. [PDF]

BMJ Open
McDonald N, Enns JE, Friesen EL, Detillieux GR, Bolton J, Weldon E, Grierson R, McDougall C, Konrad G, Leong C, Doupe M, Nickel NC.   +11 more
europepmc   +1 more source

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Distinct extracellular architectures shape mechanical persistence in GPVI and CLEC-2 receptor assemblies. [PDF]

PLoS Comput Biol
Zhang Y, Cheng Y, Soe HN, Xu Z.
europepmc   +1 more source

On the Relative Intrusiveness of Physical and Chemical Restraints

AJOB Neuroscience
De Marco, Gabriel, Douglas, Thomas, Forsberg, Lisa, Savulescu, Julian   +3 more
openaire   +2 more sources

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

"It gave me a sense of control in a treatment where I felt I had none": the use of social stories and preferences to reduce the use of restraint during nasogastric tube feeding in young people with anorexia nervosa. [PDF]

Front Psychiatry
Duffy F, Freak R, Peebles I, Cockburn J, Watson K, Manning C, West H, Austin A.   +7 more
europepmc   +1 more source

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

Physical Restraint: An Algorithm

The Internet Journal of Academic Physician Assistants, 1999
  +4 more sources

Restraint-Free Initiation of Dupilumab in a Child With Autism Spectrum Disorder: Overcoming Procedural Barriers in Atopic Dermatitis. [PDF]

J Dermatol
Yamai T, Yamamoto-Hanada K, Yonemichi H, Yamamoto S, Jimbo C, Yaguchi T, Suzuki D, Umezawa K, Hirai S, Toyokuni K, Kubota M, Fukuie T.   +11 more
europepmc   +1 more source

Yoda1‐Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair

Advanced Science, EarlyView.
Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng, Ang Wang, Ren Zhang, Xu‐Ran Li, Po‐Lin Liu, Shu‐Hang He, Zi‐Yin Han, Zhi‐Han Shen, Zhan‐Ying Wei, Chang‐Ru Zhang, Fei Wang, Helen Dawes, Jian Lu, Tong‐He Zhu, Jin‐Zhong Zhao, Shang‐Chun Guo, Shi‐Cong Tao   +16 more
wiley   +1 more source