Results 191 to 200 of about 46,850 (259)

A Mouse Model of Depression‐Tumor Multimorbidity Reveals the Mechanism of Tumor Growth Accelerated by Depression

open access: yesAnimal Research and One Health, EarlyView.
Depression accelerates tumor growth by dysregulation of tumor immune microenvironment. (A) Modeling methods: Subcutaneous tumor models were established under chronic unpredictable mild stress conditions, including cold swimming, physical restraint, and food/water deprivation, leading to increased tumor growth.
Yakun Ren   +6 more
wiley   +1 more source

Minimal Reduction in Patellar Height Following Anteromedializing Tibial Tubercle Osteotomy With Medial Patellofemoral Ligament Reconstruction

open access: yesArthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To assess whether anteromedializing tibial tubercle osteotomy (AMZ TTO) results in reduction in patellar height when performed alongside medial patellofemoral ligament reconstruction (MPFLR) for the treatment of patellar instability. Methods We performed a retrospective review of patients who underwent AMZ TTO with MPFLR between 2017 and 2024 ...
Divesh Sachdev   +7 more
wiley   +1 more source

Translateral and Transtibial Techniques Provide Similar Patient Outcomes in Arthroscopic Anterior Cruciate Ligament Reconstruction

open access: yesArthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To compare the outcomes of the transtibial technique (TT) and the translateral technique (TLL) for anterior cruciate ligament (ACL) reconstruction in an Asian population. Methods Patients who underwent either TT or TLL for ACL reconstruction between 2019 and 2021 were identified.
Joel Yat Seng Wong   +2 more
wiley   +1 more source

TWEAK/Fn14 Signaling Drives Oxidative Cardiac Injury in Systemic Lupus Erythematosus: Evidence From Patient Biomarker Studies, Lupus Mouse Models, and Cardiomyocyte Assays

open access: yesArthritis &Rheumatology, EarlyView.
Objective Cardiac involvement is a major cause of morbidity in systemic lupus erythematosus (SLE). Tumor necrosis factor–like weak inducer of apoptosis (TWEAK) is elevated in SLE, but its contribution to lupus‐associated cardiac injury is unclear. We investigated the role of TWEAK/fibroblast growth factor–inducible 14 (Fn14) signaling in SLE‐related ...
Yale Liu   +12 more
wiley   +1 more source

Dnmt3a Mutations Limit Normal and Autoreactive CD4+ T Follicular Helper Responses and Attenuate T Cell–Driven Joint Inflammation

open access: yesArthritis &Rheumatology, EarlyView.
Objective Somatic DNMT3A mutations are the most common drivers of clonal hematopoiesis in patients with rheumatoid arthritis (RA) and have been associated with seropositive disease and increased markers of inflammation. These mutations are predominantly hypomorphic or dominant‐negative, reducing DNMT3A function.
Yunbing Shen   +10 more
wiley   +1 more source

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