Results 211 to 220 of about 5,965,661 (287)

Prevalence and Predictors of Mechanical Restraint in Involuntary Patients in an Open-Door Inpatient Psychiatric Unit. [PDF]

Actas Esp Psiquiatr
Fernandez-Ribas A, Jimenez-Fernandez B, Vasquez M, Vargas-Puertolas L, Romero-Diaz E, Delgado-Mari M, Miro-Mezquita L, Cuevas-Esteban J.   +7 more
europepmc   +1 more source

Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes

Advanced Science, EarlyView.
Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao, Zhangrong Cheng, Xianglong Chen, Wenbo Wu, Wang Wu, Zimu Yu, Cao Yang, Yukun Zhang   +7 more
wiley   +1 more source

Navigating communication barriers in phlebotomy: Strategies and ethical tensions in routine care. [PDF]

PEC Innov
Diep S, Purdy L, VanSpronsen A.
europepmc   +1 more source

ZMIZ2–DUX4–LGR5 Signaling Axis Maintains Stemness Properties and Facilitates Docetaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study identifies ZMIZ2 as a therapeutic target for docetaxel‐resistant triple‐negative breast cancer, sustaining cancer stemness‐associated properties and docetaxel resistance. ZMIZ2 upregulation enhances DUX4‐mediated LGR5 activation through the SWI/SNF components BRG1 and BAF57.
Xueting Gan, Shulei Sun, Ran Hu, Yuheng Feng, Xinhao Wu, Fangqi Liu, Xuyong Lin, Xiupeng Zhang, Xuezhu Rong, Qiang Han   +9 more
wiley   +1 more source

Hypothalamic POMC Neurons Gate the Fear‐Feeding Trade‐Off

Advanced Science, EarlyView.
Hungry animals must continually arbitrate between feeding and defensive behaviors when confronted with potential threats. We show that hypothalamic POMC neurons engage CRH‐expressing stress circuits and downstream hormonal responses to coordinate this behavioral selection between competing behaviors.
Cristina Miralpeix, Abel Eraso‐Pichot, Vincent Simon, Victor Jouque, Melissa Sadallah, Samantha Clark, Philippe Zizzari, Urszula Skupio, Ana Covelo, Nathalie Dupuy, Jean Charles Nicolas, Astrid Cannich, Thierry Leste‐Lasserre, Guillaume Laplagne, Carmelo Quarta, Giovanni Marsicano, Daniela Cota   +16 more
wiley   +1 more source

Feasibility of Using Digital Clinical Records to Identify Factors Associated with Nursing-Sensitive Outcomes During Hospitalization: A Pilot Study. [PDF]

Nurs Rep
Finiguerra I, Gianino MM, Vacchelli R, Demasi M, Pappalardo L, Albanese C, Binello E, Borghin G, Cappello S, Cavagnini N, Durante S, Ferraris A, Gorgonzola F, Munaro B, Pellegrino S, Russo C, Tedino L, Minniti D, Di Gioia S.   +18 more
europepmc   +1 more source

An Explainable Multimodal Deep‐Learning Model Using Histopathological Image and Clinical Information for Prognosis Prediction in Colorectal Cancer: A Multi‐Center Cohort Study

Advanced Science, EarlyView.
This study develops a multimodal deep‐learning model that integrates clinical variables and histopathological images to predict survival outcomes in colorectal cancer. The multimodal model effectively stratifies patients into low‐ and high‐risk groups, demonstrating superior accuracy and generalizability across multiple independent cohorts.
Zhihan Jiang, Xiangchao Shi, Chenghan Su, Yao Ma, Rui Li, Menglei Chen, Jianxin Cui, Nicholas Hawkins, Robyn Ward, Xiangzhi Bai, Jitendra Jonnagaddala, Wei Fu, Xin Zhou   +12 more
wiley   +1 more source

A service evaluation of restraint, seclusion and escalation in inpatient mental health care: a retrospective observational study in England

Ugwuocha NW, Bifarin O, Shoko C, Nielson S, Challinor A, Morgan D, Jones A, Hallett N, Joyce D.   +8 more
europepmc   +1 more source

pH‐Responsive Nanoplatform‐Mediated Lipid Hijacking and Metabolic Collapse for Synergistic Starvation‐Immunotherapy

Advanced Science, EarlyView.
A pH‐responsive ZIF‐8/2‐DG@Cu‐TA nanoplatform orchestrates multifaceted metabolic disruption for synergistic starvation‐immunotherapy. Acid‐triggered 2‐DG release blocks glycolysis, while Zn2+ overload induces mitochondrial dysfunction. Concurrently, Cx43‐mediated gap junctions redirect lipid droplets from tumor cells to cancer‐associated fibroblasts ...
Xianlong Zong, Haochen Yao, Danyang Shen, Furu Gong, Zixuan Wang, Haoyang Qin, Yang Yang, Ruirui Qiao, Yongjuan Li, Rui Li   +9 more
wiley   +1 more source

A cross-sectional study of the associations between intuitive eating and maladaptive eating behaviors in Brazilian University students. [PDF]

Eat Weight Disord
Yavorivski A, Ruiz AC, Poínhos R, Feoli AMP.   +3 more
europepmc   +1 more source