Results 21 to 30 of about 65,038 (219)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
A Hybrid Nonlinear Whale Optimization Algorithm with Sine Cosine for Global Optimization
BiomimeticsThe whale optimization algorithm (WOA) is constructed on a whale’s bubble-net scavenging pattern and emulates encompassing prey, bubble-net devouring prey, and stochastic capturing for prey to establish the global optimal values.
Yubao Xu, Jinzhong Zhang
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Earth-Venus Mission Analysis via Weak Capture and Nonlinear Orbit Control
Aerospace, 2023 Exploration of Venus is recently driven by the interest of the scientific community in understanding the evolution of Earth-size planets, and is leading the implementation of missions that can benefit from new design techniques and technology.
Giulio De Angelis +3 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
On the Convergence of a Kurchatov-Type Method for Solving Nonlinear Equations and Its Applications
AppliedMathA local and a semi-local convergence analysis are presented for the Kurchatov-type method to solve numerically nonlinear equations in a Banach space. The method depends on a real parameter. By specializing the parameter, we obtain methods already studied
Ioannis K. Argyros +2 more
doaj +1 more source
IEEE Access, 2018 This paper investigates downlink (DL) channel estimation of frequency division duplex (FDD) massive multiple-input-multiple-output (MIMO) with a finite number of base station (BS) antennas.
Sanaz Rezvani Kenarsari +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source