Results 31 to 40 of about 54,884 (212)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A Hybrid Nonlinear Whale Optimization Algorithm with Sine Cosine for Global Optimization

Biomimetics
The whale optimization algorithm (WOA) is constructed on a whale’s bubble-net scavenging pattern and emulates encompassing prey, bubble-net devouring prey, and stochastic capturing for prey to establish the global optimal values.
Yubao Xu, Jinzhong Zhang
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Mobility-Aware Reconstruction Algorithm for Correlated Nonzero Neighborhood Structured Downlink Channel in Massive MIMO

IEEE Access, 2018
This paper investigates downlink (DL) channel estimation of frequency division duplex (FDD) massive multiple-input-multiple-output (MIMO) with a finite number of base station (BS) antennas.
Sanaz Rezvani Kenarsari, Mahmoud Ferdosizade Naeiny   +1 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Sea surface currents and geographic isolation shape the genetic population structure of a coral reef fish in the Indian Ocean.

PLoS ONE, 2018
In this contribution, we determine the genetic population structure in the Skunk Clownfish (Amphiprion akallopsisos) across the Indian Ocean, and on a smaller geographic scale in the Western Indian Ocean (WIO).
Filip Huyghe, Marc Kochzius
doaj   +1 more source

Precision photon spectra for wino annihilation

Journal of High Energy Physics, 2019
We provide precise predictions for the hard photon spectrum resulting from neutral SU(2) W triplet (wino) dark matter annihilation. Our calculation is performed utilizing an effective field theory expansion around the endpoint region where the photon ...
Matthew Baumgart, Timothy Cohen, Emmanuel Moulin, Ian Moult, Lucia Rinchiuso, Nicholas L. Rodd, Tracy R. Slatyer, Iain W. Stewart, Varun Vaidya   +8 more
doaj   +1 more source

Aerosol-induced changes of convective cloud anvils produce strong climate warming [PDF]

Atmospheric Chemistry and Physics, 2010
The effect of aerosol on clouds poses one of the largest uncertainties in estimating the anthropogenic contribution to climate change. Small human-induced perturbations to cloud characteristics via aerosol pathways can create a change in the top-of ...
I. Koren, L. A. Remer, O. Altaratz, J. V. Martins, A. Davidi   +4 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source