Results 41 to 50 of about 54,884 (212)

On the Convergence of a Kurchatov-Type Method for Solving Nonlinear Equations and Its Applications

AppliedMath
A local and a semi-local convergence analysis are presented for the Kurchatov-type method to solve numerically nonlinear equations in a Banach space. The method depends on a real parameter. By specializing the parameter, we obtain methods already studied
Ioannis K. Argyros, Stepan Shakhno, Halyna Yarmola   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Dietary convergence induces individual responses in faecal microbiome composition

eGastroenterology
Background Dietary variation has been identified as a key contributor to microbiome diversification. However, assessing its true impact in a cross-sectional setting is complicated by biological confounders and methodological hurdles. We aimed to estimate
Gwen Falony, Séverine Vermeire, Raul Y Tito, Sara Vieira-Silva, Jeroen Raes, Christophe Matthys, João Sabino, Sebastian Proost, Astrid Vermeulen, Erik Bootsma, Gunter Kathagen, Jorge F Vázquez-Castellanos   +11 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Quad Rapidly-Exploring Random Tree Star Algorithm With Improved Potential Force for Unmanned Aerial Vehicle Path Planning

IEEE Access
Rapidly-exploring random tree star (RRT*) has attracted intensive attention in track planning due to its asymptotic optimal properties. However, the RRT* algorithm plans costly trajectory paths.
Peng Bian, Jiaming Fan, Yang Liu, Xia Chen, Yu Wang   +4 more
doaj   +1 more source

Metastable Resting State Brain Dynamics

Frontiers in Computational Neuroscience, 2019
Metastability refers to the fact that the state of a dynamical system spends a large amount of time in a restricted region of its available phase space before a transition takes place, bringing the system into another state from where it might recur into
Peter beim Graben, Antonio Jimenez-Marin, Ibai Diez, Ibai Diez, Ibai Diez, Jesus M. Cortes, Jesus M. Cortes, Jesus M. Cortes, Mathieu Desroches, Mathieu Desroches, Serafim Rodrigues, Serafim Rodrigues   +11 more
doaj   +1 more source

HLA-driven convergence of HIV-1 viral subtypes B and F toward the adaptation to immune responses in human populations. [PDF]

PLoS ONE, 2008
BACKGROUND: Cytotoxic T-Lymphocyte (CTL) response drives the evolution of HIV-1 at a host-level by selecting HLA-restricted escape mutations. Dissecting the dynamics of these escape mutations at a population-level would help to understand how HLA ...
Dario Alberto Dilernia, Leandro Jones, Sabrina Rodriguez, Gabriela Turk, Andrea E Rubio, Sandra Pampuro, Manuel Gomez-Carrillo, Christian T Bautista, Gabriel Deluchi, Jorge Benetucci, María Beatriz Lasala, Leonardo Lourtau, Marcelo Horacio Losso, Héctor Perez, Pedro Cahn, Horacio Salomón   +15 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Mitigating Selection Bias in Local Optima: A Meta-Analysis of Niching Methods in Continuous Optimization

Information
As mainstream solvers for black-box optimization problems, evolutionary computation (EC) methods struggle with finding desired optima of lower attractiveness.
Junchen Wang, Changhe Li, Yiya Diao
doaj   +1 more source

Exploring Entanglement and Optimization within the Hamiltonian Variational Ansatz

PRX Quantum, 2020
Quantum variational algorithms are one of the most promising applications of near-term quantum computers; however, recent studies have demonstrated that unless the variational quantum circuits are configured in a problem-specific manner, optimization of ...
Roeland Wiersema, Cunlu Zhou, Yvette de Sereville, Juan Felipe Carrasquilla, Yong Baek Kim, Henry Yuen   +5 more
doaj   +1 more source