Results 121 to 130 of about 178,886 (297)

On the stochastic restricted Liu-type maximum likelihood estimator in logistic regression model

, 2019
In order to overcome multicollinearity, we propose a stochastic restricted Liu-type maximum likelihood estimator by incorporating Liu-type maximum likelihood estimator to the logistic regression model when the linear restrictions are stochastic.
Wu, Jibo, Asar, Yasin
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Improving Heritability Estimates with Restricted Maximum Likelihood (ReML)

, 2017
Poster submitted to OHBM 2009.
Nichols, Thomas, Friston, Karl, Roiser, JP, Viding, E   +3 more
openaire   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

ESTIMASI MAXIMUM LIKELIHOOD DAN RESTRICTED MAXIMUM LIKELIHOOD UNTUK MODEL LINEAR EFEK CAMPURAN

, 2014
Linier mixed effects model (LME) is one of parametric linier regression for clustered, longitudinal, or repeated measures data that quantifies the relationship between a continous dependent variabel and independent variable.
, Dr. Gunardi, M.Si, , ADIANTO PANGARIBUAN   +1 more
core  

Image pair and examiner effects on corresponding minutia counts, showing restricted maximum likelihood estimates.

, 2014
(n = 2796 responses by 165 examiners to 231 mated image pairs)Image pair and examiner effects on corresponding minutia counts, showing restricted maximum likelihood estimates.
Bradford T. Ulery (178068), R. Austin Hicklin (178073), Maria Antonia Roberts (178083), JoAnn Buscaglia (178077)   +3 more
core   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

CHARACTERIZING UNCERTAIN OUTCOMES WITH THE RESTRICTED HT TRANSFORMATION

Restrictions on the hyperbolic trigonometric (HT) transformation are imposed to guarantee that a probability density function is obtained from the maximum likelihood estimation.
Moffitt, L. Joe
core