Results 101 to 110 of about 724,462 (280)

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

FEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes, Maria X. Isaksen, Frida Julbø, Manohar Pradhan, Andreas Kleppe, Sepp De Raedt, Ole‐Johan Skrede, Turid Torheim, John Arne Nesheim, Hans Martin Mohn, Hanne A. Askautrud, Karolina Cyll, Wanja Kildal, Emma Rewcastle, Melinda Lillesand, Vebjørn Kvikstad, Emiel Janssen, Robert Jones, Odd Terje Brustugun, Bjørn Brennhovd, Erik Skaaheim Haug, Lill‐Tove Rasmussen Busund, Elin Richardsen, Sigve Andersen, Tom Dønnem, Kristina Lindemann, Gunnar Kristensen, Neil A. Shepherd, Marco Novelli, Knut Liestøl, David Kerr, Håvard E. Danielsen, Tarjei S. Hveem   +32 more
wiley   +1 more source

Modelos animais alternativos para estimação de componentes de (co)variância e de parâmetros genéticos e fenotípicos do peso ao nascer na raça Nelore Alternative animal models to estimate (co) variance components and genetic and phenotypic parameters for birth weight in Nellore cattle

Revista Brasileira de Zootecnia, 1999
O objetivo deste trabalho foi estudar os aspectos genético-quantitativos do peso ao nascer (PN), de animais da raça Nelore, em rebanhos participantes do Programa de Melhoramento Genético da Raça Nelore, realizado pelo Departamento de Genética da ...
Márcia Tereza Vieira Scarpati, Raysildo Barbosa Lôbo   +1 more
doaj   +1 more source

Asymptotic Properties of Pseudo Maximum Likelihood Estimates for Multiple Frequency I(1) Processes [PDF]

In this paper we derive (weak) consistency and the asymptotic distribution of pseudo maximum likelihood estimates for multiple frequency I(1) processes.
Dietmar Bauer, Martin Wagner
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Maximum Likelihood Estimation of the I(2) Model under Linear Restrictions [PDF]

Econometrics, 2017
Estimation of the I(2) cointegrated vector autoregressive (CVAR) model is considered. Without further restrictions, estimation of the I(1) model is by reduced-rank regression (Anderson (1951)). Maximum likelihood estimation of I(2) models, on the other hand, always requires iteration.
openaire   +4 more sources

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Inference in Graphical Gaussian Models with Edge and Vertex Symmetries with the gRc Package for R [PDF]

In this paper we present the R package gRc for statistical inference in graphical Gaussian models in which symmetry restrictions have been imposed on the concentration or partial correlation matrix.
Steffen L. Lauritzen, Søren Højsgaard
core   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Selection of Stable Lentil Genotypes for Rainfed Conditions Using Multivariate Methods

Legume Science
In order to assess the stability of 16 lentil genotypes, experiments were carried out across multiple locations (Lorestan, Gachsaran, and Ilam) over two growing seasons (2021–2023), with Mogan evaluated in one season (2021–2022).
Payam Pezeshkpour, Peyman Sharifi, Reza Amiri, Ammin Namdari, Amir Mirzaei, Asghar Mehraban   +5 more
doaj   +1 more source

Balancing signature variance between local and global minima/maxima: Restricted maximum likelihood (REML) classification and the search for plagioclimax

Ecological Informatics
Due to long-term anthropogenic disturbance, plagioclimax results in vegetation compositions that cannot develop to a climax state. The overarching goal of the study was to develop a method to identify plagioclimax sub-regionally in the eastern ...
N. Manspeizer, A. Karnieli
doaj   +1 more source