Results 91 to 100 of about 724,462 (280)

Fast Stable Restricted Maximum Likelihood and Marginal Likelihood Estimation of Semiparametric Generalized Linear Models [PDF]

Journal of the Royal Statistical Society Series B: Statistical Methodology, 2010
SummaryRecent work by Reiss and Ogden provides a theoretical basis for sometimes preferring restricted maximum likelihood (REML) to generalized cross-validation (GCV) for smoothing parameter selection in semiparametric regression. However, existing REML or marginal likelihood (ML) based methods for semiparametric generalized linear models (GLMs) use ...
openaire   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Does the Acknowledgement of αS1-Casein Genotype Affect the Estimation of Genetic Parameters and Prediction of Breeding Values for Milk Yield and Composition Quality-Related Traits in Murciano-Granadina?

Animals, 2019
A total of 2090 lactation records for 710 Murciano-Granadina goats were collected during the years 2005−2016 and analyzed to investigate the influence of the αS1-CN genotype on milk yield and components (protein, fat, and dry matter).
María Gabriela Pizarro Inostroza, Vincenzo Landi, Francisco Javier Navas González, Jose Manuel León Jurado, Amparo Martínez Martínez, Javier Fernández Álvarez, Juan Vicente Delgado Bermejo   +6 more
doaj   +1 more source

Combining Structural-Equation Modeling with Genomic-Relatedness-Matrix Restricted Maximum Likelihood in OpenMx. [PDF]

Behav Genet, 2021
Kirkpatrick RM, Pritikin JN, Hunter MD, Neale MC.   +3 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Consistency of Restricted Maximum Likelihood Estimators in High-Dimensional Kernel Linear Mixed-Effects Models with Applications in Estimating Genetic Heritability

Mathematics
Restricted maximum likelihood (REML) estimators are commonly used to obtain unbiased estimators for the variance components in linear mixed models. In modern applications, particularly in genomic studies, the dimension of the design matrix with respect ...
Xiaoxi Shen, Qing Lu
doaj   +1 more source

Mixture model for inferring susceptibility to mastitis in dairy cattle: a procedure for likelihood-based inference

Genetics Selection Evolution, 2004
A Gaussian mixture model with a finite number of components and correlated random effects is described. The ultimate objective is to model somatic cell count information in dairy cattle and to develop criteria for genetic selection against mastitis, an ...
Jensen Just, Madsen Per, Sorensen Daniel, Klemetsdal Gunnar, Heringstad Bjørg, Øegård Jørgen, Gianola Daniel, Detilleux Johann   +7 more
doaj   +1 more source

Exact Rational Expectations, Cointegration, and Reduced Rank Regression [PDF]

We interpret the linear relations from exact rational expectations models as restrictions on the parameters of the statistical model called the cointegrated vector autoregressive model for non-stationary variables.
Anders Rygh Swensen, Soren Johansen
core  

ESTIMASI PARAMETER PADA MODEL REGRESI LINIER MULTILEVEL DENGAN METODE RESTRICTED MAXIMUM LIKELIHOOD (REML) [PDF]

, 2011
Individu dan lingkungan dapat membentuk suatu sistem yang berstruktur hierarki. Permasalahan khusus pada data hierarki adalah menganalisis data pada level yang berbeda. Model multilevel dapat menjadi solusi untuk permasalahan ini, dimana model multilevel
DIANTI, ISNI RAKHMI
core  

Computing log-likelihood and its derivatives for restricted maximum likelihood methods

, 2016
11
openaire   +2 more sources