Results 71 to 80 of about 178,886 (297)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

A Simple Argument Showing How to Derive Restricted Maximum Likelihood

Journal of Dairy Science, 1993
Abstract This paper presents a pedagogical argument to explain to quantitative geneticists how REML can be derived from maximum likelihood for estimation of variance components. The argument is first developed for N independent normal observations with mean μ and variance σ 2 and is afterward extended to a general linear mixed model structure, y ∼ N ...
openaire   +2 more sources

Efficient Implementation of the New Restricted Maximum Likelihood Algorithms

Journal of Dairy Science, 1989
Abstract Recently tridiagonalization and diagonalization have been proposed as methods to speed the EM algorithm for variance component estimation in restricted maximum likelihood. These methods require approximately the same computing resources, but only if the most efficient strategies are employed.
S.P. Smith, C.Y. Lin
openaire   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Identifying, Estimating and Testing Restricted Cointegrated Systems: An Overview [PDF]

The notion of cointegration has lead to a renewed interest in the identification and estimation of structural relations among economic time series, a field to which Henri Theil has made many pioneering contributions.
Jurgen Doornik, H. Peter Boswijk
core  

On non-negative estimation of variance components in mixed linear models

Journal of Advanced Research, 2016
Alternative estimators have been derived for estimating the variance components according to Iterative Almost Unbiased Estimation (IAUE). As a result two modified IAUEs are introduced.
Heba A. El Leithy, Zakaria A. Abdel Wahed, Mohamed S. Abdallah   +2 more
doaj   +1 more source

CORE GREML for estimating covariance between random effects in linear mixed models for complex trait analyses

Nature Communications, 2020
Linear mixed models have bias due to the assumed independence between random effects. Here, the authors describe a genome-based restricted maximum likelihood, CORE GREML, which estimates covariance between random effects.
Xuan Zhou, Hae Kyung Im, S. Hong Lee
doaj   +1 more source

Genetic analysis of growth curve in Moghani Sheep using Bayesian and restricted maximum likelihood. [PDF]

J Anim Sci, 2023
Rashedi Dehsahraei A, Ghaderi-Zefrehei M, Rafeie F, Zakizadeh S, Shirani Shamsabadi J, Elahi Torshizi M, Neysi S, Rahmatalla SA.   +7 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Asymptotic Properties of Pseudo Maximum Likelihood Estimates for Multiple Frequency I(1) Processes [PDF]

In this paper we derive (weak) consistency and the asymptotic distribution of pseudo maximum likelihood estimates for multiple frequency I(1) processes.
Martin Wagner, Dietmar Bauer
core