Nature Communications, 2020 Linear mixed models have bias due to the assumed independence between random effects. Here, the authors describe a genome-based restricted maximum likelihood, CORE GREML, which estimates covariance between random effects.
Xuan Zhou, Hae Kyung Im, S. Hong Lee
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Restricted maximum-likelihood method for learning latent variance components in gene expression data with known and unknown confounders. [PDF]
G3 (Bethesda), 2022 Malik MA, Michoel T.
europepmc +1 more source
Efficient Implementation of the New Restricted Maximum Likelihood Algorithms
Journal of Dairy Science, 1989 Abstract Recently tridiagonalization and diagonalization have been proposed as methods to speed the EM algorithm for variance component estimation in restricted maximum likelihood. These methods require approximately the same computing resources, but only if the most efficient strategies are employed.
S.P. Smith, C.Y. Lin
openaire +1 more source
Maximum Likelihood Estimation of Latent Affine Processes [PDF]
This article develops a direct filtration-based maximum likelihood methodology for estimating the parameters and realizations of latent affine processes.
David S. Bates
core
Consistency and asymptotic normality of the maximum likelihood estimator in a zero-inflated generalized Poisson regression [PDF]
, 2005 Poisson regression models for count variables have been utilized in many applications. However, in many problems overdispersion and zero-inflation occur.
Min, Aleksey, Czado, Claudia
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
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Revista Brasileira de Zootecnia, 2009 Para estimar parâmetros genéticos e a tendência genética e fenotípica para peso à desmama (PD), peso ao sobreano (PS), ganho médio diário do nascimento à desmama (GMDND), ganho médio diário da desmama ao sobreano (GMDDS), dias para atingir 160 kg na fase
Jader Silva Lopes +5 more
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Evaluating the performance of Bayesian and restricted maximum likelihood estimation for stepped wedge cluster randomized trials with a small number of clusters. [PDF]
BMC Med Res Methodol, 2022 Grantham KL +4 more
europepmc +1 more source
Identifying, Estimating and Testing Restricted Cointegrated Systems: An Overview [PDF]
The notion of cointegration has lead to a renewed interest in the identification and estimation of structural relations among economic time series, a field to which Henri Theil has made many pioneering contributions.
Jurgen Doornik, H. Peter Boswijk
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source