Results 141 to 150 of about 226,996 (233)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Characterization of the Staphylococcus xylosus methylome reveals a new variant of type I restriction modification system in staphylococci. [PDF]

Front Microbiol, 2023
Schiffer CJ, Grätz C, Pfaffl MW, Vogel RF, Ehrmann MA.   +4 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Various plasmid strategies limit the effect of bacterial restriction-modification systems against conjugation. [PDF]

Nucleic Acids Res
Dimitriu T, Szczelkun MD, Westra ER.
europepmc   +2 more sources

Lactococcal mobile genetic elements harbour a diverse phage defensome rich in restriction-modification systems. [PDF]

Nucleic Acids Res
McDonnell B, Kelleher P, Fomenkov A, Charneco GO, Coughlan K, Quénée P, Kulakauskas S, Cambillau C, Anton BP, de Waal PP, van Peij NNME, Bottacini F, Mahony J, Roberts RJ, van Sinderen D, van Sinderen D.   +15 more
europepmc   +1 more source

Uncovering the link between the SpnIII restriction modification system and LuxS in Streptococcus pneumoniae meningitis isolates. [PDF]

Front Cell Infect Microbiol, 2023
Agnew HN, Atack JM, Fernando ARD, Waters SN, van der Linden M, Smith E, Abell AD, Brazel EB, Paton JC, Trappetti C.   +9 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

The early injected genomic region determines sensitivity to Type I restriction-modification defence against Autographiviridae phages. [PDF]

Nucleic Acids Res
Martinez-Cazorla A, Martinez-Jimenez C, Elio-Lucas P, Fineran PC, Jackson S, Sanchez-Amat A.   +5 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Regulation of a phage defence island by RptR, a novel repressor that controls restriction-modification systems in diverse bacteria. [PDF]

Nucleic Acids Res
Zhang Y, Schuller M, Ahel I, Blower TR, Exley RM, Tang CM.   +5 more
europepmc   +1 more source