Results 41 to 50 of about 1,050,756 (279)

A sequential one-pot approach for rapid and convenient characterization of putative restriction-modification systems

mSystems, 2023
With the advance of high-throughput sequencing, the molecular basis of coevolutionary interaction between viruses and host microorganisms is predominantly elucidated by in silico genomic analyses, which revealed potential communication of genetic ...
Yi Zhang, Yoshihiro Takaki, Yukari Yoshida-Takashima, Satoshi Hiraoka, Kanako Kurosawa, Takuro Nunoura, Ken Takai   +6 more
doaj   +1 more source

Characterization of a Novel N4-Methylcytosine Restriction-Modification System in Deinococcus radiodurans. [PDF]

Int J Mol Sci
Shi C, Wang L, Xu H, Zhao Y, Tian B, Hua Y.   +5 more
europepmc   +3 more sources

Reassembling a cannon in the DNA defense arsenal: Genetics of StySA, a BREX phage exclusion system in Salmonella lab strains.

PLoS Genetics, 2022
Understanding mechanisms that shape horizontal exchange in prokaryotes is a key problem in biology. A major limit on DNA entry is imposed by restriction-modification (RM) processes that depend on the pattern of DNA modification at host-specified sites ...
Julie Zaworski, Oyut Dagva, Julius Brandt, Chloé Baum, Laurence Ettwiller, Alexey Fomenkov, Elisabeth A Raleigh   +6 more
doaj   +1 more source

Delineation of a lactococcal conjugation system reveals a restriction‐modification evasion system

Microbial Biotechnology, 2023
Plasmid pUC11B is a 49.3‐kb plasmid harboured by the fermented meat isolate Lactococcus lactis subsp. lactis UC11. Among other features, pUC11B encodes a pMRC01‐like conjugation system and tetracycline‐resistance.
Guillermo Ortiz Charneco, Philip Kelleher, Andrius Buivydas, Sofia Dashko, Paul P. deWaal, Noël N. M. E. vanPeij, Richard J. Roberts, Jennifer Mahony, Douwe vanSinderen   +8 more
doaj   +1 more source

Sau1: a Novel Lineage-Specific Type I Restriction-Modification System That Blocks Horizontal Gene Transfer into Staphylococcus aureus and between S. aureus Isolates of Different Lineages

Journal of Bacteriology, 2006
Denise E. Waldron, Jodi A. Lindsay
openalex   +2 more sources

The Hyperthermophilic Restriction-Modification Systems of Thermococcus kodakarensis Protect Genome Integrity

Frontiers in Microbiology, 2021
Thermococcus kodakarensis (T. kodakarensis), a hyperthermophilic, genetically accessible model archaeon, encodes two putative restriction modification (R-M) defense systems, TkoI and TkoII.
Kelly M. Zatopek, Brett W. Burkhart, Richard D. Morgan, Alexandra M. Gehring, Kristin A. Scott, Thomas J. Santangelo, Andrew F. Gardner   +6 more
doaj   +1 more source

Comparative Methylome Analysis of Campylobacter jejuni Strain YH002 Reveals a Putative Novel Motif and Diverse Epigenetic Regulations of Virulence Genes

Frontiers in Microbiology, 2020
Campylobacter jejuni is a major cause of foodborne gastroenteritis worldwide inflicting palpable socioeconomic costs. The ability of this pathogen to successfully infect its hosts is determined not only by the presence of specific virulence genes but ...
Sandeep Ghatak, Cheryl M. Armstrong, Sue Reed, Yiping He   +3 more
doaj   +1 more source

Functional comparison of anti-restriction and anti-methylation activities of ArdA, KlcA, and KlcAHS from Klebsiella pneumoniae

Frontiers in Cellular and Infection Microbiology, 2022
Anti-restriction proteins are typically encoded by plasmids, conjugative transposons, or phages to improve their chances of entering a new bacterial host with a type I DNA restriction and modification (RM) system.
Huimin Chen, Shuan Tao, Na Li, Fang Wang, Lei Wang, Yu Tang, Wei Liang   +6 more
doaj   +1 more source

Pathological phenotypes and in vivo DNA cleavage by unrestrained activity of a phosphorothioate-based restriction system in Salmonella [PDF]

, 2014
Prokaryotes protect their genomes from foreign DNA with a diversity of defence mechanisms, including a widespread restriction–modification (R–M) system involving phosphorothioate (PT) modification of the DNA backbone. Unlike classical R–M systems, highly
Cao, Bo, Cheng, Qiuxiang, Dedon, Peter C., DeMott, Michael S., Deng, Zixin, Gu, Chen, Yao, Fen, You, Delin, Zheng, Xiaoqing   +8 more
core   +1 more source

Generation of a restriction minus enteropathogenic Escherichia coli E2348/69 strain that is efficiently transformed with large, low copy plasmids

BMC Microbiology, 2008
Background Many microbes possess restriction-modification systems that protect them from parasitic DNA molecules. Unfortunately, the presence of a restriction-modification system in a given microbe also hampers genetic analysis.
Ward Jordan D, Price Nancy L, Hobson Neil, Raivio Tracy L   +3 more
doaj   +1 more source