Bacterial Autoimmunity Due to a Restriction-Modification System [PDF]
Current Biology, 2016 Restriction-modification (RM) systems represent a minimal and ubiquitous biological system of self/non-self discrimination in prokaryotes [1], which protects hosts from exogenous DNA [2]. The mechanism is based on the balance between methyltransferase (M) and cognate restriction endonuclease (R).
Pleška, Maroš +6 more
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A mobile restriction modification system consisting of methylases on the IncA/C plasmid [PDF]
Mobile DNA, 2019 Background IncA/C plasmids play important roles in the development and dissemination of multidrug resistance in bacteria. These plasmids carry three methylase genes, two of which show cytosine specificity.
Ruibai Wang, Jing Lou, Jie Li
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From sequence to activity: the HgaI-homologous restriction modification system RM.MhoVI of Mycoplasma hominis [PDF]
BMC MicrobiologyRestriction-modification (RM) systems are widespread defense mechanisms in prokaryotes that protect the host from potentially harmful foreign DNA. They typically consist of a DNA methyltransferase (MTase), which methylates the host genome at an adenine ...
Lars Vogelgsang +5 more
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Deletion of the Zinc Transporter Lipoprotein AdcAII Causes Hyperencapsulation of
mBio, 2020 The capsule is the dominant Streptococcus pneumoniae virulence factor, yet how variation in capsule thickness is regulated is poorly understood. Here, we describe an unexpected relationship between mutation of adcAII, which encodes a zinc uptake ...
Claire Durmort +11 more
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MspGI Restriction–Modification System and Its Flanking Genes of Microbacterium sp. Gd 4-13
Biology and Life Sciences ForumBacteria have defense systems against the penetration of foreign DNA (phages and plasmids). Some defense systems protect bacteria from phage penetration into the cell, while others block phage replication. Antiphage defense systems are often located next
Alfiya K. Yunusova +3 more
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Development of a CRISPR-based cytosine base editor for restriction-modification system inactivation to enhance transformation efficiency in Vibrio Sp. dhg [PDF]
Journal of Biological EngineeringBackground Vibrio sp. dhg is a fast-growing, alginate-utilizing, marine bacterium being developed as a platform host for macroalgae biorefinery. To maximize its potential in the production of various value-added products, there is a need to expand ...
Yang Jun Shon +5 more
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Uncovering the link between the SpnIII restriction modification system and LuxS in Streptococcus pneumoniae meningitis isolates. [PDF]
Front Cell Infect Microbiol, 2023 Streptococcus pneumoniae is capable of randomly switching their genomic DNA methylation pattern between six distinct bacterial subpopulations (A-F) via recombination of a type 1 restriction-modification locus, spnIII.
Agnew HN +9 more
europepmc +2 more sources
Low-level expression of the Type II restriction-modification system confers potent bacteriophage resistance in Escherichia coli. [PDF]
DNA Res, 2020 Wilkowska K +3 more
europepmc +2 more sources
mSystems, 2023 With the advance of high-throughput sequencing, the molecular basis of coevolutionary interaction between viruses and host microorganisms is predominantly elucidated by in silico genomic analyses, which revealed potential communication of genetic ...
Yi Zhang +6 more
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Plasmid pEC156, a Naturally Occurring Escherichia coli Genetic Element That Carries Genes of the EcoVIII Restriction-Modification System, Is Mobilizable among Enterobacteria. [PDF]
PLoS ONE, 2016 Type II restriction-modification systems are ubiquitous in prokaryotes. Some of them are present in naturally occurring plasmids, which may facilitate the spread of these systems in bacterial populations by horizontal gene transfer.
Olesia Werbowy, Tadeusz Kaczorowski
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