A Survey of Archaeal Restriction–Modification Systems [PDF]
Microorganisms, 2023 When compared with bacteria, relatively little is known about the restriction–modification (RM) systems of archaea, particularly those in taxa outside of the haloarchaea.
Brian P. Anton, Richard J. Roberts
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The DNA Phosphorothioation Restriction-Modification System Influences the Antimicrobial Resistance of Pathogenic Bacteria [PDF]
Microbiology Spectrum, 2023 Bacterial defense barriers, such as DNA methylation-associated restriction-modification (R-M) and the CRISPR-Cas system, play an important role in bacterial antimicrobial resistance (AMR).
Congrui Xu +9 more
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The Restriction–Modification Systems of Clostridium carboxidivorans P7 [PDF]
Microorganisms, 2023 Clostridium carboxidivorans P7 (DSM 15243) is a bacterium that converts syngas (a mixture of CO, H2, and CO2) into hexanol. An optimized and scaled-up industrial process could therefore provide a renewable source of fuels and chemicals while consuming ...
Patrick Kottenhahn +4 more
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The evolutionary replacement of restriction-modification by Ssp antiviral systems is associated with the distribution of prophages in the major clonal group of Acinetobacter baumannii [PDF]
mBioBacteriophages kill almost half of the world’s bacterial cells every day. In response, bacteria have developed anti-phage defense mechanisms that number in the dozens.
Antonio Moreno-Rodríguez +4 more
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The extremophile Picrophilus torridus carries a DNA adenine methylase M.PtoI that is part of a Type I restriction-modification system [PDF]
Frontiers in Microbiology, 2023 DNA methylation events mediated by orphan methyltransferases modulate various cellular processes like replication, repair and transcription. Bacteria and archaea also harbor DNA methyltransferases that are part of restriction-modification systems, which ...
Pallavi Gulati +3 more
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Restriction modification systems in archaea: A panoramic outlook [PDF]
HeliyonRestriction modification (RM) systems are one of the ubiquitous yet primitive defense responses employed by bacteria and archaea with the primary role of safeguarding themselves against invading bacteriophages.
Pallavi Gulati +4 more
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Restriction-modification systems and prophages drive genomic diversification in Priestia megaterium [PDF]
Biology DirectBacteria are frequently stressed by bacteriophages. Priestia megaterium is a bacterium of both agricultural and biotechnological importance, yet it has been unclear how the interplay between phage-imposed stress and bacterial immunity shapes the genome ...
Miao Wang +6 more
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Dependence of post-segregational killing mediated by Type II restriction–modification systems on the lifetime of restriction endonuclease effective activity [PDF]
mBioPlasmid-borne Type II restriction–modification (RM) systems mediate post-segregational killing (PSK). PSK is thought to be caused by the dilution of restriction and modification enzymes during cell division, resulting in accumulation of unmethylated DNA ...
Svetlana Kozlova +3 more
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Anti-plasmid defense in hypervirulent Klebsiella pneumoniae involves Type I-like and Type IV restriction modification systems [PDF]
Emerging Microbes and InfectionsHypervirulent Klebsiella pneumoniae (hvKp) and classical multidrug-resistant (MDR) strains belong to distinct lineages and hvKp are typically characterized by hypermucoid capsules that have been shown to limit horizontal gene transfer (HGT), including ...
Guodong Oo +7 more
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Frontiers in Microbiology, 2022 The restriction-modification (RM) systems are compared to a primitive, innate, prokaryotic immune system, controlling the invasion by foreign DNA, composed of methyltransferase (MTase) and restriction endonuclease.
Monika Adamczyk-Poplawska +5 more
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