Restriction modification systems in archaea: A panoramic outlook [PDF]
HeliyonRestriction modification (RM) systems are one of the ubiquitous yet primitive defense responses employed by bacteria and archaea with the primary role of safeguarding themselves against invading bacteriophages.
Pallavi Gulati +4 more
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Dependence of post-segregational killing mediated by Type II restriction–modification systems on the lifetime of restriction endonuclease effective activity [PDF]
mBioPlasmid-borne Type II restriction–modification (RM) systems mediate post-segregational killing (PSK). PSK is thought to be caused by the dilution of restriction and modification enzymes during cell division, resulting in accumulation of unmethylated DNA ...
Svetlana Kozlova +3 more
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Distribution of Type I Restriction–Modification Systems in Streptococcus suis: An Outlook [PDF]
Pathogens, 2016 Streptococcus suis is a porcine commensal and pathogen with zoonotic potential. We recently identified a novel Type I restriction–modification (R–M) system in a zoonotic S. suis clone which has emerged in the Netherlands.
Niels Willemse, Constance Schultsz
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A Survey of Archaeal Restriction–Modification Systems [PDF]
Microorganisms, 2023 When compared with bacteria, relatively little is known about the restriction–modification (RM) systems of archaea, particularly those in taxa outside of the haloarchaea.
Brian P. Anton, Richard J. Roberts
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The Restriction–Modification Systems of Clostridium carboxidivorans P7 [PDF]
Microorganisms, 2023 Clostridium carboxidivorans P7 (DSM 15243) is a bacterium that converts syngas (a mixture of CO, H2, and CO2) into hexanol. An optimized and scaled-up industrial process could therefore provide a renewable source of fuels and chemicals while consuming ...
Patrick Kottenhahn +4 more
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Broadness and specificity: ArdB, ArdA, and Ocr against various restriction-modification systems [PDF]
Frontiers in Microbiology, 2023 ArdB, ArdA, and Ocr proteins inhibit the endonuclease activity of the type I restriction-modification enzymes (RMI). In this study, we evaluated the ability of ArdB, ArdA, and Ocr to inhibit different subtypes of Escherichia coli RMI systems (IA, IB, and
Anna A. Kudryavtseva +12 more
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The Hyperthermophilic Restriction-Modification Systems of Thermococcus kodakarensis Protect Genome Integrity [PDF]
Frontiers in Microbiology, 2021 Thermococcus kodakarensis (T. kodakarensis), a hyperthermophilic, genetically accessible model archaeon, encodes two putative restriction modification (R-M) defense systems, TkoI and TkoII.
Kelly M. Zatopek +6 more
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Restriction-modification systems and prophages drive genomic diversification in Priestia megaterium [PDF]
Biology DirectBacteria are frequently stressed by bacteriophages. Priestia megaterium is a bacterium of both agricultural and biotechnological importance, yet it has been unclear how the interplay between phage-imposed stress and bacterial immunity shapes the genome ...
Miao Wang +6 more
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Removal and bypass of restriction modification systems increases transformation efficiency of Thermococcus kodakarensis [PDF]
Frontiers in MicrobiologyArchaea are increasingly recognized as key participants in global nutrient cycles, as idealized platforms for biotechnological applications, and as the progenitors of Eukarya.
Alexander M. Alon +5 more
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Structural and functional diversity among Type III restriction-modification systems that confer host DNA protection via methylation of the N4 atom of cytosine. [PDF]
PLoS ONE, 2021 We report a new subgroup of Type III Restriction-Modification systems that use m4C methylation for host protection. Recognition specificities for six such systems, each recognizing a novel motif, have been determined using single molecule real-time DNA ...
Iain A Murray +9 more
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