Restriction Modification Systems as Engines of Diversity [PDF]
Frontiers in Microbiology, 2015 Restriction modification (RM) systems provide protection against a broad spectrum of phages. However, the likelihood of a phage permanently bypassing this can be as high as 0.1 per infection (Korona et al., J. Gen. Microbiol.
Kim eSneppen +3 more
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Restriction modification systems in archaea: A panoramic outlook [PDF]
HeliyonRestriction modification (RM) systems are one of the ubiquitous yet primitive defense responses employed by bacteria and archaea with the primary role of safeguarding themselves against invading bacteriophages.
Pallavi Gulati +4 more
doaj +7 more sources
Broadness and specificity: ArdB, ArdA, and Ocr against various restriction-modification systems [PDF]
Frontiers in Microbiology, 2023 ArdB, ArdA, and Ocr proteins inhibit the endonuclease activity of the type I restriction-modification enzymes (RMI). In this study, we evaluated the ability of ArdB, ArdA, and Ocr to inhibit different subtypes of Escherichia coli RMI systems (IA, IB, and
Anna A. Kudryavtseva +12 more
doaj +4 more sources
A Survey of Archaeal Restriction–Modification Systems [PDF]
Microorganisms, 2023 When compared with bacteria, relatively little is known about the restriction–modification (RM) systems of archaea, particularly those in taxa outside of the haloarchaea.
Brian P. Anton, Richard J. Roberts
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Avoidance of recognition sites of restriction-modification systems is a widespread but not universal anti-restriction strategy of prokaryotic viruses [PDF]
BMC Genomics, 2018 Background Restriction-modification (R-M) systems protect bacteria and archaea from attacks by bacteriophages and archaeal viruses. An R-M system specifically recognizes short sites in foreign DNA and cleaves it, while such sites in the host DNA are ...
I. S. Rusinov +4 more
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Distribution of Type I Restriction–Modification Systems in Streptococcus suis: An Outlook [PDF]
Pathogens, 2016 Streptococcus suis is a porcine commensal and pathogen with zoonotic potential. We recently identified a novel Type I restriction–modification (R–M) system in a zoonotic S. suis clone which has emerged in the Netherlands.
Niels Willemse, Constance Schultsz
doaj +5 more sources
Toxin/antitoxin systems induce persistence and work in concert with restriction/modification systems to inhibit phage [PDF]
Microbiology Spectrum, 2023 Myriad bacterial anti-phage systems have been described and often the mechanism of programmed cell death is invoked for phage inhibition. However, there is little evidence of “suicide” under physiological conditions for these systems. Instead of death to
Laura Fernández-García +6 more
doaj +3 more sources
Enhanced Fusobacterium nucleatum Genetics Using Host DNA Methyltransferases To Bypass Restriction-Modification Systems [PDF]
Journal of Bacteriology, 2022 Fusobacterium nucleatum is an oral opportunistic pathogen associated with diseases that include cancer and preterm birth. Our understanding of how this bacterium modulates human disease has been hindered by a lack of genetic systems.
Ariana Umana +2 more
exaly +3 more sources
DNA sequence repeats identify numerous Type I restriction-modification systems that are potential epigenetic regulators controlling phase-variable regulons; phasevarions [PDF]
FASEB J, 2020 Over recent years several examples of randomly switching methyltransferases, associated with Type III restriction‐modification (R‐M) systems, have been described in pathogenic bacteria.
Yang, Long +4 more
core +3 more sources
DNA methylation by three Type I restriction modification systems of Escherichia coli does not influence gene regulation of the host bacterium [PDF]
Nucleic Acids Research, 2021 DNA methylation is a common epigenetic mark that influences transcriptional regulation, and therefore cellular phenotype, across all domains of life.
Swaine L Chen
exaly +3 more sources