Results 31 to 40 of about 728,418 (291)

Moraxella catarrhalis Restriction-Modification Systems Are Associated with Phylogenetic Lineage and Disease. [PDF]

Genome Biol Evol, 2018
Moraxella catarrhalis is a human-adapted pathogen, and a major cause of otitis media (OM) and exacerbations of chronic obstructive pulmonary disease. The species is comprised of two main phylogenetic lineages, RB1 and RB2/3. Restriction–modification (R-M)
Blakeway LV, Tan A, Lappan R, Ariff A, Pickering JL, Peacock CS, Blyth CC, Kahler CM, Chang BJ, Lehmann D, Kirkham LS, Murphy TF, Jennings MP, Bakaletz LO, Atack JM, Peak IR, Seib KL.   +16 more
europepmc   +2 more sources

Restriction-modification systems and prophages drive genomic diversification in Priestia megaterium [PDF]

Biology Direct
Bacteria are frequently stressed by bacteriophages. Priestia megaterium is a bacterium of both agricultural and biotechnological importance, yet it has been unclear how the interplay between phage-imposed stress and bacterial immunity shapes the genome ...
Miao Wang, Chuyang Shao, Juan Ignacio Vílchez, Danxia He, Lixian Chen, Jin-Lin Zhang, Huiming Zhang   +6 more
doaj   +2 more sources

Advances in Diversity, Evolutionary Dynamics and Biotechnological Potential of Restriction-Modification Systems [PDF]

Microorganisms
Restriction–modification systems (RMS) are ubiquitous in prokaryotes and serve as primitive immune-like mechanisms that safeguard microbial genomes against foreign genetic elements.
Chen Chen, Yue Zhang, Hao Wu, Jianjun Qiao, Qinggele Caiyin   +4 more
doaj   +2 more sources

A model for the evolution of prokaryotic DNA restriction-modification systems based upon the structural malleability of Type I restriction-modification enzymes. [PDF]

Nucleic Acids Res, 2018
Restriction Modification (RM) systems prevent the invasion of foreign genetic material into bacterial cells by restriction and protect the host's genetic material by methylation.
Bower EKM, Cooper LP, Roberts GA, White JH, Luyten Y, Morgan RD, Dryden DTF.   +6 more
europepmc   +2 more sources

Novel m4C modification in type I restriction-modification systems. [PDF]

Nucleic Acids Res, 2016
We identify a new subgroup of Type I Restriction-Modification enzymes that modify cytosine in one DNA strand and adenine in the opposite strand for host protection.
Morgan RD, Luyten YA, Johnson SA, Clough EM, Clark TA, Roberts RJ.   +5 more
europepmc   +2 more sources

Effects of mutations in phage restriction sites during escape from restriction–modification

Biology Letters, 2017
Restriction–modification systems are widespread genetic elements that protect bacteria from bacteriophage infections by recognizing and cleaving heterologous DNA at short, well-defined sequences called restriction sites. Bioinformatic evidence shows that
Călin C. Guet, Guet, Calin C ; https://orcid.org/, Maroš Pleška, Pleska, Maros ; https://orcid.org/   +3 more
core   +2 more sources

Systematic Analysis of REBASE Identifies Numerous Type I Restriction-Modification Systems with Duplicated, Distinct hsdS Specificity Genes That Can Switch System Specificity by Recombination [PDF]

mSystems, 2020
N6-Adenine DNA methyltransferases associated with some Type I and Type III restriction-modification (R-M) systems are able to undergo phase variation, randomly switching expression ON or OFF by varying the length of locus-encoded simple sequence repeats (
Yang, Long, Zhou, Yaoqi, Litfin, Thomas, Guo, Chengying, Atack, John M, Jennings, Michael P, Blackall, Patrick J   +6 more
core   +2 more sources

Highly efficient CRISPR-Cas9 base editing in Bifidobacterium with bypass of restriction modification systems [PDF]

Applied and Environmental Microbiology
Intestinal microbiota members of the Bifidobacterium genus are increasingly explored as probiotics and therapeutics. However, the paucity of genetic tools and the widespread restriction modification (RM) systems in Bifidobacterium limit our ability to ...
Hung-Chun Lin, Wan-Chi Hsiao, Ya-Chen Hsu, Meng-Chieh Lin, Cheng-Chih Hsu, Mingzi M. Zhang   +5 more
doaj   +2 more sources

Comparative Genomics Reveals the Diversity of Restriction-Modification Systems and DNA Methylation Sites in Listeria monocytogenes. [PDF]

Appl Environ Microbiol, 2017
Listeria monocytogenes is a bacterial pathogen that is found in a wide variety of anthropogenic and natural environments. Genome sequencing technologies are rapidly becoming a powerful tool in facilitating our understanding of how genotype ...
Chen P, den Bakker HC, Korlach J, Kong N, Storey DB, Paxinos EE, Ashby M, Clark T, Luong K, Wiedmann M, Weimer BC.   +10 more
europepmc   +2 more sources

Restriction-Modification Systems as Mobile Genetic Elements in the Evolution of an Intracellular Symbiont. [PDF]

Mol Biol Evol, 2016
Long-term vertical transmission of intracellular bacteria causes massive genomic erosion and results in extremely small genomes, particularly in ancient symbionts.
Zheng H, Dietrich C, Hongoh Y, Brune A.
europepmc   +2 more sources