Results 31 to 40 of about 10,132,911 (226)

Reassembling a cannon in the DNA defense arsenal: Genetics of StySA, a BREX phage exclusion system in Salmonella lab strains.

PLoS Genetics, 2022
Understanding mechanisms that shape horizontal exchange in prokaryotes is a key problem in biology. A major limit on DNA entry is imposed by restriction-modification (RM) processes that depend on the pattern of DNA modification at host-specified sites ...
Julie Zaworski, Oyut Dagva, Julius Brandt, Chloé Baum, Laurence Ettwiller, Alexey Fomenkov, Elisabeth A Raleigh   +6 more
doaj   +1 more source

Bacterial DNA methyltransferase: A key to the epigenetic world with lessons learned from proteobacteria

Frontiers in Microbiology, 2023
Epigenetics modulates expression levels of various important genes in both prokaryotes and eukaryotes. These epigenetic traits are heritable without any change in genetic DNA sequences. DNA methylation is a universal mechanism of epigenetic regulation in
Qun Gao, Qun Gao, Shuwei Lu, Shuwei Lu, Yuwei Wang, Longgui He, Longgui He, Mingshu Wang, Mingshu Wang, Mingshu Wang, Renyong Jia, Renyong Jia, Renyong Jia, Shun Chen, Shun Chen, Shun Chen, Dekang Zhu, Dekang Zhu, Dekang Zhu, Mafeng Liu, Mafeng Liu, Mafeng Liu, Xinxin Zhao, Xinxin Zhao, Xinxin Zhao, Qiao Yang, Qiao Yang, Qiao Yang, Ying Wu, Ying Wu, Ying Wu, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Juan Huang, Juan Huang, Juan Huang, Sai Mao, Sai Mao, Sai Mao, Xumin Ou, Xumin Ou, Xumin Ou, Di Sun, Di Sun, Di Sun, Bin Tian, Bin Tian, Bin Tian, Anchun Cheng, Anchun Cheng, Anchun Cheng   +51 more
doaj   +1 more source

Adaptative Potential of the Lactococcus Lactis IL594 Strain Encoded in Its 7 Plasmids [PDF]

, 2011
The extrachromosomal gene pool plays a significant role both in evolution and in the environmental adaptation of bacteria. The L. lactis subsp. lactis IL594 strain contains seven plasmids, named pIL1 to pIL7, and is the parental strain of the plasmid ...
Roman K Górecki, Marcin Grynberg, Górecki Roman K., Grynberg Marcin, Koryszewska-Bagińska, Anna, Marcin Gołębiewski, Jacek K Bardowski, Roman K. Górecki, Grynberg, Marcin, Gołębiewski, Marcin, Żylińska Joanna, Żylińska, Joanna, Górecki, Roman Krzysztof, Bardowski Jacek K., Anna Koryszewska-Bagińska, Bardowski, Jacek K., Joanna Żylińska, Jacek K. Bardowski, Gołębiewski Marcin, Koryszewska-Bagińska Anna   +19 more
core   +2 more sources

Fused eco29kIR- and M genes coding for a fully functional hybrid polypeptide as a model of molecular evolution of restriction-modification systems

BMC Evolutionary Biology, 2011
Background The discovery of restriction endonucleases and modification DNA methyltransferases, key instruments of genetic engineering, opened a new era of molecular biology through development of the recombinant DNA technology.
Solonin Alexander S, Mokrishcheva Marina L, Nikitin Dmitri V   +2 more
doaj   +1 more source

Epigenetic Regulation of Virulence and Immunoevasion by Phase-Variable Restriction-Modification Systems in Bacterial Pathogens

, 2020
Human-adapted bacterial pathogens use a mechanism called phase variation to randomly switch the expression of individual genes to generate a phenotypically diverse population to adapt to challenges within and between human hosts.
Atack, JM, Srikhanta, YN, Jennings, MP, Seib, KL   +3 more
core   +1 more source

DNA methylation assessed by SMRT sequencing is linked to mutations in Neisseria meningitidis isolates [PDF]

, 2015
The Gram-negative bacterium Neisseria meningitidis features extensive genetic variability. To present, proposed virulence genotypes are also detected in isolates from asymptomatic carriers, indicating more complex mechanisms underlying variable ...
Gerd Pluschke, Christoph D. Schmid (72046), Schmid, Christoph D., Mane, Shrikant, Korlach, Jonas, Tyson A. Clark (105783), Katharina Röltgen, Wang, Guilin, Araceli Lamelas, Jonas Korlach (105788), Shrikant Mane, Araceli Lamelas (128475), Christoph D Schmid, Mohamad R Abdul Sater, Clark, Tyson A., Röltgen, Katharina, Gerd Pluschke (7855), Katharina Röltgen (120045), Guilin Wang, Sater, Mohamad R. Abdul, Tyson A Clark, Mohamad R. Abdul Sater (836669), Jonas Korlach, Guilin Wang (37620), Shrikant Mane (106631), Lamelas, Araceli, Pluschke, Gerd   +26 more
core   +1 more source

Generation of a restriction minus enteropathogenic Escherichia coli E2348/69 strain that is efficiently transformed with large, low copy plasmids

BMC Microbiology, 2008
Background Many microbes possess restriction-modification systems that protect them from parasitic DNA molecules. Unfortunately, the presence of a restriction-modification system in a given microbe also hampers genetic analysis.
Ward Jordan D, Price Nancy L, Hobson Neil, Raivio Tracy L   +3 more
doaj   +1 more source

Vibrio cholerae pathogenicity island 2 encodes two distinct types of restriction systems [PDF]

In response to predation by bacteriophages and invasion by other mobile genetic elements such as plasmids, bacteria have evolved specialized defense systems that are often clustered together on genomic islands.
Vizzarro, Grazia, Adams, David William, Blokesch, Melanie, Lemopoulos, Alexandre   +3 more
core   +2 more sources

A DNA phosphorothioation-based Dnd defense system provides resistance against various phages and is compatible with the Ssp defense system

mBio, 2023
DndABCDE-catalyzed DNA phosphorothioation (PT), in which the nonbridging oxygen is swapped with a sulfur atom, was first identified in the bacterial genome.
Susu Jiang, Ke Chen, Yingying Wang, Yueying Zhang, Yaru Tang, Wanqiu Huang, Xiaolin Xiong, Shi Chen, Chao Chen, Lianrong Wang   +9 more
doaj   +1 more source

Systematic Analysis of REBASE Identifies Numerous Type I Restriction-Modification Systems with Duplicated, Distinct hsdS Specificity Genes That Can Switch System Specificity by Recombination. [PDF]

mSystems, 2020
N6-Adenine DNA methyltransferases associated with some Type I and Type III restriction-modification (R-M) systems are able to undergo phase variation, randomly switching expression ON or OFF by varying the length of locus-encoded simple sequence repeats (
Atack JM, Guo C, Litfin T, Yang L, Blackall PJ, Zhou Y, Jennings MP.   +6 more
europepmc   +2 more sources