Restriction Modification Systems as Engines of Diversity [PDF]
Frontiers in Microbiology, 2015 Restriction modification (RM) systems provide protection against a broad spectrum of phages. However, the likelihood of a phage permanently bypassing this can be as high as 0.1 per infection (Korona et al., J. Gen. Microbiol.
Kim eSneppen +3 more
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Avoidance of recognition sites of restriction-modification systems is a widespread but not universal anti-restriction strategy of prokaryotic viruses [PDF]
BMC Genomics, 2018 Background Restriction-modification (R-M) systems protect bacteria and archaea from attacks by bacteriophages and archaeal viruses. An R-M system specifically recognizes short sites in foreign DNA and cleaves it, while such sites in the host DNA are ...
I. S. Rusinov +4 more
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Interplay Between Bacteriophages and Restriction-Modification Systems in Enterococci
Nova Biotechnologica et Chimica, 2014 The complete genomes of Enterococcus faecalis bacteriophages were analyzed for tetranucleotide words avoidance. Very similar tetranucleotide composition was found in all tested genomes with strong underrepresentation of palindromic GATC and GGCC words ...
Pristas Peter +2 more
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IS-linked movement of a restriction-modification system. [PDF]
PLoS ONE, 2011 Potential mobility of restriction-modification systems has been suggested by evolutionary/bioinformatic analysis of prokaryotic genomes. Here we demonstrate in vivo movement of a restriction-modification system within a genome under a laboratory ...
Noriko Takahashi +4 more
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Restriction-modification systems in Mycoplasma spp [PDF]
Genetics and Molecular Biology, 2007 Restriction and Modification (R-M) systems are present in all Mycoplasma species sequenced so far. The presence of these genes poses barriers to gene transfer and could protect the cell against phage infections.
Marcelo Brocchi +2 more
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Advances in Diversity, Evolutionary Dynamics and Biotechnological Potential of Restriction-Modification Systems [PDF]
MicroorganismsRestriction–modification systems (RMS) are ubiquitous in prokaryotes and serve as primitive immune-like mechanisms that safeguard microbial genomes against foreign genetic elements.
Chen Chen +4 more
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Toxin/antitoxin systems induce persistence and work in concert with restriction/modification systems to inhibit phage [PDF]
Microbiology SpectrumMyriad bacterial anti-phage systems have been described and often the mechanism of programmed cell death is invoked for phage inhibition. However, there is little evidence of “suicide” under physiological conditions for these systems. Instead of death to
Laura Fernández-García +6 more
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Evading native restriction-modification systems improves electroporation efficiency of the methanotroph Methylococcus capsulatus Bath [PDF]
Applied and Environmental MicrobiologyMethylococcus capsulatus Bath is a unique methanotrophic bacterium that uses methane (CH4) as a carbon and energy source and encodes the RubisCO enzyme for inorganic carbon assimilation, positioning it as an excellent candidate for biotechnology to ...
Yao-Chuan Yu +7 more
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Highly efficient CRISPR-Cas9 base editing in Bifidobacterium with bypass of restriction modification systems [PDF]
Applied and Environmental MicrobiologyIntestinal microbiota members of the Bifidobacterium genus are increasingly explored as probiotics and therapeutics. However, the paucity of genetic tools and the widespread restriction modification (RM) systems in Bifidobacterium limit our ability to ...
Hung-Chun Lin +5 more
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Enhanced Fusobacterium nucleatum Genetics Using Host DNA Methyltransferases To Bypass Restriction-Modification Systems. [PDF]
J Bacteriol, 2022 Umaña A +5 more
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