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BMC Microbiology, 2008 Background Many microbes possess restriction-modification systems that protect them from parasitic DNA molecules. Unfortunately, the presence of a restriction-modification system in a given microbe also hampers genetic analysis.
Ward Jordan D +3 more
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Frontiers in Cellular and Infection Microbiology, 2022 Anti-restriction proteins are typically encoded by plasmids, conjugative transposons, or phages to improve their chances of entering a new bacterial host with a type I DNA restriction and modification (RM) system.
Huimin Chen +6 more
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Structural and mutagenic analysis of the RM controller protein C.Esp1396I [PDF]
, 2014 Bacterial restriction-modification (RM) systems are comprised of two complementary enzymatic activities that prevent the establishment of foreign DNA in a bacterial cell: DNA methylation and DNA restriction.
Martin, Richard N. A. +8 more
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Restriction-modification systems and plasmids
, 2023 This folder contains supplementary data files for the paper Restriction-modification systems have shaped the evolution and distribution of plasmids across bacteria (2022) Liam P. Shaw, Eduardo P. C. Rocha, R. Craig MacLean.
Liam Shaw (5487083)
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Enhanced transformation efficiency of recalcitrant Bacillus cereus and Bacillus weihenstephanensis isolates upon in vitro methylation of plasmid DNA [PDF]
, 2008 Digestion patterns of chromosomal DNAs of Bacillus cereus and Bacillus weihenstephanensis strains suggest that Sau3AI-type restriction modification systems are widely present among the isolates tested.
Abee, T. +5 more
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Cloning and Expression of the BalI Restriction-modification System [PDF]
Nucleic Acids Research, 1996 BalI, a type II restriction-modification (R-M) system from the bacterium, Brevibacterium albidum, recognizes the DNA sequence 5'-TGGCCA-3'. We cloned the genes encoding the BalI restriction endonuclease and methyltransferase and expressed them in Escherichia coli. The two genes were aligned tail-to-tail and their termination codons overlapped.
H, Ueno, I, Kato, Y, Ishino
openaire +2 more sources
Methylome-dependent transformation of emm1 group A streptococci
mBio, 2023 Genetic intractability presents a fundamental barrier to the manipulation of bacteria, hindering advancements in microbiological research. Group A Streptococcus (GAS), a lethal human pathogen currently associated with an unprecedented surge of infections
Joana Alves +4 more
doaj +1 more source
Structural basis for broad anti-phage immunity by DISARM
Nature Communications, 2022 DISARM (Defense Island System Associated with Restriction Modification) systems can provide bacteria with protection against a wide range of phage. Here, Bravo et al.
Jack P. K. Bravo +4 more
doaj +1 more source
The Restriction–Modification Systems of Clostridium carboxidivorans P7
Microorganisms, 2023 Clostridium carboxidivorans P7 (DSM 15243) is a bacterium that converts syngas (a mixture of CO, H2, and CO2) into hexanol. An optimized and scaled-up industrial process could therefore provide a renewable source of fuels and chemicals while consuming ...
Patrick Kottenhahn +4 more
doaj +1 more source
Transcription regulation of restriction-modification system Ecl18kI [PDF]
Nucleic Acids Research, 2009 Restriction-modification (R-M) system Ecl18kI is representative of R-M systems whose coordinated transcription is achieved through a separate DNA-binding domain of the methyltransferase. M.Ecl18kI recognizes an operator sequence located in the noncoding region that separates the divergently transcribed R and M genes.
Protsenko, Alexey +4 more
openaire +2 more sources