Results 191 to 200 of about 620,807 (343)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Novel triple-target panels utilizing methylation-sensitive restriction enzyme-based quantitative PCR for detecting advanced cervical precancers and cancers among high-risk HPV-positive women. [PDF]

J Transl Med
Chen S, Dai H, Hu S, Gao T, Chen M, Zhou X, Dai L, Zhao X, Zhao F.   +8 more
europepmc   +1 more source

DeepH&M: Estimating single-CpG hydroxymethylation and methylation levels from enrichment and restriction enzyme sequencing methods. [PDF]

Sci Adv, 2020
He Y, Jang HS, Xing X, Li D, Vasek MJ, Dougherty JD, Wang T.   +6 more
europepmc   +1 more source

The Deoxyribonucleic Acid Modification and Restriction Enzymes of Escherichia coli B

, 1972
Barnet Eskin, Stuart Linn
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

I-PREFR: Inverse PCR-Based Restriction Enzyme FRee Unidirectional Strategy for Rapid Markerless Chromosomal Gene Deletion and Reconstitution in Bacteria Using Suicide Vectors. [PDF]

Bio Protoc
Rana R, Sharma A, Dutta A, Patil PB.
europepmc   +1 more source

DISCRIMINATION OF LISTERIA MONOCYTOGENES STRAINS OF SEROTYPE 4b BY RESTRICTION ENZYME ANALYSIS OF CHROMOSOMAL DNA

, 1997
Akinobu Saito, Takuo Sawada, Yoshikazu TOKUMARU, Ryo Hondo   +3 more
openalex   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

A validated restriction enzyme ddPCR cg05575921 (AHRR) assay to accurately assess smoking exposure. [PDF]

Clin Epigenetics
Fitzgerald S, Bhat B, Print C, Jones GT.
europepmc   +1 more source