Results 91 to 100 of about 288,437 (264)
RECAP-seq: restriction enzyme-based CpG-methylated fragment amplification for early cancer detection
Scientific ReportsAberrant DNA methylation drives cancer development, yet current screening methods require substantial resources for targeted enrichment across multiple CpG-rich regions.
Dongju Shin +5 more
doaj +1 more source
Identification and discrimination of Theileria annulata by polymerase chain reaction-restriction fragment length polymorphism. [PDF]
Vet World, 2022 Selim A, Khater H.
europepmc +1 more source
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Molecular detection of fluoroquinolone-resistant Neisseria meningitidis by using mismatched PCR-restriction fragment length polymorphism technique. [PDF]
Front Cell Infect Microbiol, 2022 Ota Y, Okada R, Takahashi H, Saito R.
europepmc +1 more source
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Genotypic confirmation of a biased phenotypic sex ratio in a dryland moss using restriction fragment length polymorphisms. [PDF]
Appl Plant Sci, 2022 Ekwealor JTB +7 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
DIABETICO-PROTECTIVE ROLE OF VITAMIN D
Pakistan Journal of Medicine and Dentistry, 2019 Studies worldwide have observed a link between VDR polymorphism and Diabetes Mellitus. Diabetes is a complex disease characterized by insulin deficiency caused by the alterations in the function of pancreatic β-cells, insulin sensitivity and systemic ...
Asif Memon +3 more
doaj
FEBS Open Bio, EarlyView.ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand +2 more
wiley +1 more source
Evaluating the Association of Genetic Polymorphism of Cytochrome p450 (CYP2C9*3) in Gastric Cancer Using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). [PDF]
Cureus, 2022 Uthansingh K +4 more
europepmc +1 more source