Results 241 to 250 of about 162,034 (262)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Untangling the mechanisms of sleep restriction therapy. [PDF]

Sleep
Stanyer EC, Skeldon AC, Kyle SD.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Dynamical study of optical soliton solutions to the Lakshmanan-Porsezian-Daniel equation by using [Formula: see text]-model expansion approach. [PDF]

Sci Rep
Alharthi MR, Inayat M, Abbas M, Birhanu A, Yousaf MZ, El-Zahar ER.   +5 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Residual-aided CSI-free end-to-end learning for multiuser MIMO. [PDF]

PLoS One
Affum EA, Futa O, Oppong MA, Biney DO.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Natural variation of the <i>GmDt1</i> gene affects the 100-seed weight of soybean. [PDF]

Front Plant Sci
Wang G, Zhao D, Hu X, Zheng H, Wang W, Bai P, Miao L, Gao H, Wang L, Sun H, Li J.   +10 more
europepmc   +1 more source

A bibliometric analysis of the intersection of circadian rhythm, anxiety disorders, aging, and comorbidity. [PDF]

Rev Assoc Med Bras (1992)
Hastaoglu F, Dumlu NO.
europepmc   +1 more source

Intraoperative functional brain mapping for glioma surgery: a comprehensive review of the University of California San Francisco mapping protocol. [PDF]

J Neurooncol
Chen JS, Bergsneider B, Haddad AF, Morshed RA, Hervey-Jumper SL, Young JS, Berger MS.   +6 more
europepmc   +1 more source