Results 181 to 190 of about 1,408,992 (336)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Effect of Middle Diol Repeat Units in Biobased Aliphatic Polyesters on Thermal and Tensile Properties. [PDF]

ACS Omega
Isami K, Miyamoto G, Abdellatif MM, Higashi S, Tao K, Hirano H, Nomura K.   +6 more
europepmc   +1 more source

Prevenção e tratamento dos agravos resultantes da violência sexual contra mulheres e adolescentes: norma técnica

, 2005
Brasil. Ministério da Saúde
openalex   +1 more source

Resultants of slice regular polynomials in two quaternionic variables [PDF]

Anna Maria Gori, Giulia Sarfatti, Fabio Vlacci   +2 more
openalex   +1 more source

Mortalidade de motociclistas com lesões traumáticas resultantes de acidentes de trânsito na cidade de São José dos Campos, em 2015: estudo de coorte [PDF]

, 2020
Caroline de Lima Neto Silva, Maria Carolina Barbosa Teixeira Lopes, Rosimey Romero Thomaz, Iveth Yamaguchi Whitaker   +3 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

A compact uniform circular array antenna for circularly polarized higher-order OAM beam generation through modes superposition. [PDF]

PLoS One
Fayyaz U, Aladadi YT, Aziz A, Niazi SA, Shah ST, Al-Sowayan S, Shamsan ZA, Hussain R.   +7 more
europepmc   +1 more source

Reliability of Portal Frames with Interacting Stress-resultants - Closure

, 1992
Luís Simões da Silva
openalex   +1 more source

Oxidative Folding: Cellular Strategies for Dealing with the Resultant Equimolar Production of Reactive Oxygen Species

, 2009
Yuichiro Shimizu, Linda M. Hendershot
openalex   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source