Results 131 to 140 of about 132,275 (287)
Phytotherapy Research, EarlyView.Pedunculoside targets and suppresses CDK4; consequently, it activates the MAPK pathway and inhibits hepatocellular carcinoma progression. ABSTRACT Hepatocellular carcinoma (HCC) remains a major challenge in cancer prevention and treatment, highlighting the urgent need for effective and low‐toxicity anti‐HCC therapies. Recently, CDK4‐targeted inhibitors
Yang Zhou +9 more
wiley +1 more source
Management of erectile dysfunction with a novel orodispersible formulation of the PDE-5 inhibitor vardenafil [PDF]
, 2011 Erectile dysfunction (ED) is a medical condition which can affect men of all ages. As men live longer and the prevalence of cardiovascular disease and diabetes continue to increase, the problem of ED will become more prominent.
Cordina, Maria
core
Phytotherapy Research, EarlyView.ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by a preclinical stage that typically lasts for decades. Early on during this time, microglia react to pathological changes and become protective and even transiently delay neurodegeneration.
Sara Merlo +3 more
wiley +1 more source
Packaging Technology and Science, EarlyView.Residues from Garcinia humilis were used to obtain a phenolic‐rich extract (GHRE) and incorporated into collagen–starch films. The addition of GHRE improved antioxidant activity, thermal stability and elasticity, while reducing water vapour permeability.
Érica da Costa Monção +7 more
wiley +1 more source
SOME PHENOLIC COMPOUNDS FROM STEM BARK OF MELINJO (GNETUM GNEMON) AND THEIR ACTIVITY TEST AS ANTIOXIDANT AND UV-B PROTECTION [PDF]
Isolation and structure elucidation of three phenolic compounds, namely 3,4-dimethoxychlorogenic acid (1), resveratrol (2), and 3-methoxyresveratrol (3) from stem bark of Melinjo (Gnetum gnemon) had been done. The isolation of those compounds was carried
Sri , Atun, Ph.D
core
Epac1 Alleviates Senescence in Auditory Hair Cells via the Ferroptosis
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Objectives The aim of this study was to investigate the changes in Epac1 and ferroptosis‐related proteins in aged mice and the House Ear Institute‐Organ of Corti 1 (HEI‐OC1) cells, with the goal of elucidating their potential role in age‐related hearing loss. Methods The expression of Epac1 in the cochlea of C57BL/6J mice was examined by using
Wen‐Jun An +7 more
wiley +1 more source
Preliminary Results on Contents of Resveratrol in Wine of Organic and Conventional Vineyards [PDF]
, 2000 Phytoalexins are compounds synthesised by plants in response to various stresses. In grapevines, these compounds belong to the stilbene family. Several studies have shown that resveratrol is usually triggered by infection of berries by Botrytis cinerea ...
Adrian, M., Lévite, D., Tamm, L.
core
Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
Point: From animal models to prevention of colon cancer. Systematic review of chemoprevention in min mice and choice of the model system. [PDF]
, 2003 The Apc(Min/+) mouse model and the azoxymethane (AOM) rat model are the main animal models used to study the effect of dietary agents on colorectal cancer. We reviewed recently the potency of chemopreventive agents in the AOM rat model (D. E.
Corpet, Denis E., Pierre, Fabrice
core +2 more sources
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source