ABSTRACT Tucum‐do‐Cerrado (Bactris setosa Mart.) is a polyphenol‐rich Brazilian fruit known to improve glucose metabolism. This study investigated its effects on brown (BAT), inguinal (iWAT), and epididymal (eWAT) adipose tissues in a diet‐induced obesity model. Rats received control (CT/TUC‐), high‐fat (HF/TUC‐), control with Tucum‐do‐Cerrado (CT/TUC+)
Marilia Hermes Cavalcanti +2 more
wiley +1 more source
An Integrated Machine-Learning and Reverse Network-Pharmacology Pipeline Reveals <i>JUN</i>/C3 Candidate Biomarkers and an Anti-Fibrotic Mechanism of Resveratrol via MAPK/JNK Signaling in Chronic Kidney Disease. [PDF]
Cai Y +6 more
europepmc +1 more source
Reactive Oxygen Species‐Induced Damage in Cryopreserved Bovine Sperm: Mitigation Strategies
Cryopreservation of bovine sperm results in overproduction of ROS due to osmotic pressure variations, ice crystals and dysfunction of mitochondria, which causes lipid peroxidation, fragmentation of DNA, protein damage and ultimately decline of post‐thaw sperm quality.
Mst. Mahomudha Akhtar +4 more
wiley +1 more source
Machine Learning Accelerates Crystallization for Structure Determination
Single‐crystal X‐ray diffraction (SCXRD) is often constrained by the difficulty of obtaining suitable crystals. Here, a machine learning‐accelerated co‐crystal discovery workflow is established for a crystalline mate strategy that achieves over 95% prediction accuracy and experimentally delivers 114 co‐crystals from 120 candidates.
Cui‐Zhou Luan +10 more
wiley +2 more sources
Resveratrol Ameliorates Diabetic Peripheral Neuropathy via the AMPK/mTOR/Bcl-2 Axis: Integrative Evidence From Network Pharmacology, Mendelian Randomization, and Binding-Site Evolutionary Constraint. [PDF]
Zhang C +5 more
europepmc +1 more source
ABSTRACT Plant‐based antioxidants are widely incorporated into foods to retard oxidative deterioration and to deliver health‐related benefits. Yet, their in‐product and in vivo performance frequently diverges from predictions based on solution‐phase chemical assays, because matrix interactions, processing history, and host metabolism reshape both ...
Márcio Vargas‐Ramella +6 more
wiley +1 more source
Resveratrol Induces Proteasomal Degradation of PTPN1 to Enhance Cisplatin Sensitivity in Epstein-Barr Virus-Associated Malignancies. [PDF]
Liu N +5 more
europepmc +1 more source
Updates on Mediterranean diet and health status: active ingredients and pharmacological mechanisms
The Mediterranean diet (MedDiet) is among the most extensively studied dietary patterns and has been consistently associated with reduced risk of all‐cause mortality, cardiovascular disease, metabolic disorders, cognitive decline and several types of cancers.
Lukas Schwingshackl +3 more
wiley +1 more source

