Results 91 to 100 of about 23,676 (191)

Precision medicine in cancer: A comprehensive review of advanced cancer diagnosis technologies and personalized treatment strategies

Precision Medical Sciences, EarlyView.
The translational pipeline of precision medicine in clinical oncology. Schematic overview of the individualized cancer care workflow. (1) Input: Patient samples undergo multi‐omic profiling via NGS, single‐cell diagnostics, spatial maps, and epigenetic sequencing.
Asif Jan, Bushra Waheed, Rani Akbar, Daniel Dubwa   +3 more
wiley   +1 more source

Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3-d]pyrimidine RET Inhibitors. [PDF]

ACS Med Chem Lett, 2021
Mathison CJN, Yang Y, Nelson J, Huang Z, Jiang J, Chianelli D, Rucker PV, Roland J, Xie YF, Epple R, Bursulaya B, Lee C, Gao MY, Shaffer J, Briones S, Sarkisova Y, Galkin A, Li L, Li N, Li C, Hua S, Kasibhatla S, Kinyamu-Akunda J, Kikkawa R, Molteni V, Tellew JE.   +25 more
europepmc   +1 more source

Carbon dots in electrochemiluminescence: Mechanisms, interface engineering, and bioanalytical applications

Responsive Materials, EarlyView.
Carbon dots are emerging as versatile electrochemiluminescent nanomaterials whose structure, surface states, and interfacial design jointly determine ECL pathways and performance. This review highlights how mechanistic understanding and materials engineering enable programmable CD‐ECL systems for bioanalysis, imaging, and future intelligent analytical ...
Yuhan Zhao, Zixuan Chen, Jun‐Jie Zhu
wiley   +1 more source

Machine learning driven drug repurposing strategy for identification of potential RET inhibitors against non-small cell lung cancer. [PDF]

Med Oncol, 2022
Ramesh P, Karuppasamy R, Veerappapillai S.   +2 more
europepmc   +1 more source

Advancing SDG 13 and Net‐Zero Emissions in Europe: The Role of Green Technology Innovation, Renewable Energy, Environmental Taxation and Trade Openness

Sustainable Development, EarlyView.
ABSTRACT The European Union (EU) has set ambitious climate goals, aiming to become the first climate‐neutral continent by 2050, with a focus on achieving net‐zero emissions and advancing United Nations Sustainable Development Goal (SDG) 13. A key component of this transition is the role of green technological innovation, the deployment of clean energy ...
Yue Xu, Emma Serwaa Obobisa, Isaac Adjei Mensah   +2 more
wiley   +1 more source

Chasing the Target: New Phenomena of Resistance to Novel Selective RET Inhibitors in Lung Cancer. Updated Evidence and Future Perspectives. [PDF]

Cancers (Basel), 2021
Fancelli S, Caliman E, Mazzoni F, Brugia M, Castiglione F, Voltolini L, Pillozzi S, Antonuzzo L.   +7 more
europepmc   +1 more source

Escaping the Regional Carbon Trap: The Role of Renewable Energy Innovation in EU Decarbonisation

Sustainable Development, EarlyView.
ABSTRACT The persistence of carbon‐intensive development pathways continues to hinder progress towards climate neutrality, especially in regions where industrial legacies, infrastructural inertia, and institutional rigidities reinforce emissions.
Kingsley Imandojemu, Felix Orole, Stephen Mmaduabuchukwu Chukwuka   +2 more
wiley   +1 more source

Evolution of treatment strategies for solid tumors with RET rearrangement in China and real-world treatment status of Non-small Cell Lung Cancer (NSCLC)

BMC Pulmonary Medicine
Objective The present study endeavors to furnish an exhaustive review of the research advancements on solid tumors harboring RET rearrangement within the Chinese context, particularly emphasizing the examination of real-world therapeutic strategies and ...
An Wang, Tao Li, Yun-ye Mao, Ming Gao, Sheng Shu, Chang-hong Xia, Yi Dong, Min Liu, Jin-liang Wang, Jun-xun Ma, Yi Hu   +10 more
doaj   +1 more source

Kinase inhibitors in thyroid cancers

Endocrine Oncology
Objective: The treatment landscape for thyroid cancers has changed rapidly with the availability of kinase inhibitors against VEGFR, BRAF, MEK, NTRK, and RET.
Vineeth Sukrithan, Prachi Jain, Manisha H Shah, Bhavana Konda   +3 more
doaj   +1 more source

Novel Human-Derived RET Fusion NSCLC Cell Lines Have Heterogeneous Responses to RET Inhibitors and Differential Regulation of Downstream Signaling. [PDF]

Mol Pharmacol, 2021
Schubert L, Le AT, Estrada-Bernal A, Doak AE, Yoo M, Ferrara SE, Goodspeed A, Kinose F, Rix U, Tan AC, Doebele RC.   +10 more
europepmc   +1 more source