Results 21 to 30 of about 1,021 (141)

ReticularNet: Automated Pixel-Level Segmentation of Reticular Pseudodrusen on Near-Infrared Reflectance Images by Deep Learning [PDF]

Ophthalmology Science
Objective: Reticular pseudodrusen (RPD) represent an important biomarker in age-related macular degeneration (AMD) but are difficult to grade and often assessed only for presence or absence, without quantitative or spatial analysis of RPD burden.
Souvick Mukherjee, PhD, Dylan Wu, Leon von der Emde, MD, Emily Vance, MPH, Marco Ji, MD, Mehdi Emamverdi, MD, Tharindu De Silva, PhD, Alisa T. Thavikulwat, MD, Jayashree Kalpathy-Cramer, PhD, Amitha Domalpally, MD, PhD, Catherine A. Cukras, MD, PhD, Tiarnán D.L. Keenan, BM BCh, PhD   +11 more
doaj   +2 more sources

HTRA1/lncRNA HTRA1-AS1 dominates in age-related macular degeneration reticular pseudodrusen genetic risk with no complement involvement [PDF]

Nature Communications
Age-related macular degeneration (AMD) is a multifactorial retinal disease with a large genetic risk contribution. Reticular pseudodrusen (RPD) is a sub-phenotype of AMD with a high risk of progression to late vision threatening AMD.
Samaneh Farashi, Carla J. Abbott, Brendan R. E. Ansell, Zhichao Wu, Lebriz Altay, Ella Arnon, Louis Arnould, Yelena Bagdasarova, Konstantinos Balaskas, Fred K. Chen, Emily Chew, Itay Chowers, Steven Clarke, Catherine Cukras, Cécile Delcourt, Marie-Noëlle Delyfer, Anneke I. den Hollander, Sascha Fauser, Robert P. Finger, Pierre-Henry Gabrielle, Jiru Han, Lauren A. B. Hodgson, Ruth Hogg, Frank G. Holz, Carel Hoyng, Himeesh Kumar, Eleonora M. Lad, Aaron Lee, Ulrich F. O. Luhmann, Matthias M. Mauschitz, Amy J. McKnight, Samuel McLenachan, Aniket Mishra, Ismail Moghul, Luz D. Orozco, Danuta M. Sampson, Liam W. Scott, Vasilena Sitnilska, Scott Song, Amy Stockwell, Anand Swaroop, Jan H. Terheyden, Liran Tiosano, Adnan Tufail, Brian L. Yaspan, MACUSTAR consortium, NICOLA consortium, Alice Pébay, Erica L. Fletcher, Robyn H. Guymer, Melanie Bahlo, On behalf of the Reticular Pseudodrusen Consortium   +51 more
doaj   +2 more sources

Patient induced pluripotent stem cells identify specificities of a reticular pseudodrusen phenotype in age-related macular degeneration [PDF]

Genome Medicine
Background Age-related macular degeneration (AMD) is a leading cause of vision loss. Reticular pseudodrusen (RPD), deposits on the apical side of the retinal pigment epithelium (RPE), signify a distinctive and critical AMD phenotype. Yet, their molecular
Jenna C. Hall, Kavitha Krishna Sudhakar, Maciej Daniszewski, Anne Senabouth, Carla J. Abbott, Helena H. Liang, Himeesh Kumar, Grace E. Lidgerwood, Mehdi Mirzaei, Jessica YW Ma, Trevor Atkeson, Yumiko Hirokawa, Emeline F. Nandrot, Alexander Barnett, Chantal Cazevieille, Gaël Manes, Simon Mountford, Philip Thompson, Erica L. Fletcher, Zhichao Wu, Melanie Bahlo, Brendan R. E. Ansell, Daniel Paull, Alex W. Hewitt, Robyn H. Guymer, Joseph E. Powell, Alice Pébay   +26 more
doaj   +2 more sources

Correlation of Histologic Features with In Vivo Imaging of Reticular Pseudodrusen [PDF]

Ophthalmology, 2016
To determine the histologic and cellular correlates in the retina and retinal pigment epithelium (RPE) with the presence of optical coherence tomography-defined reticular pseudodrusen (RPD).Observation case using immunocytochemistry of an exenterated eye with immediate fixation after removal.Two patients, one with confirmed RPD and the other with mid ...
Erica Fletcher, Robyn Guymer, Ursula Greferath   +2 more
exaly   +4 more sources

Electrophysiological function in eyes with reticular pseudodrusen according to fundus distribution. [PDF]

PLoS ONE, 2018
Reticular pseudodrusen (RPD) could be present not only in the posterior pole but extramacular area also as a confluent morphological pattern. Thus RPD can be classified by the fundus distribution for the assessment of visual prognosis.
Mingui Kong, Jaemoon Yoon, Don-Il Ham
doaj   +2 more sources

Complement factors and reticular pseudodrusen in intermediate age-related macular degeneration staged by multimodal imaging [PDF]

BMJ Open Ophthalmology, 2020
Objective Systemic activation of the complement system in intermediate age-related macular degeneration (AMD) is understudied. Moreover, links between the presence of reticular pseudodrusen (RPD) and systemic complement dysregulation have not been ...
Anne M Lynch, Alan G Palestine, Brandie D Wagner, Jennifer L Patnaik, Ashley A Frazier-Abel, Marc T Mathias, Frank S Siringo, Vernon Michael Holers, Naresh Mandava   +8 more
doaj   +2 more sources

Reticular Pseudodrusen [PDF]

Ophthalmology, 2014
Gregory Hageman, Lauren Ayton, Chi Luu   +2 more
exaly   +2 more sources

Deep Learning-Based Detection of Reticular Pseudodrusen in Age-Related Macular Degeneration. [PDF]

Clin Exp Ophthalmol
ABSTRACT Background Reticular pseudodrusen (RPD) signify a critical phenotype driving vision loss in age‐related macular degeneration (AMD). This study sought to develop and externally test a deep learning (DL) model to detect RPD on optical coherence tomography (OCT) scans with expert‐level performance.
Kumar H, Bagdasarova Y, Song S, Hickey DG, Cohn AC, Okada M, Finger RP, Terheyden JH, Hogg RE, Gabrielle PH, Arnould L, Jannaud M, Hadoux X, van Wijngaarden P, Abbott CJ, Hodgson LAB, Schwartz R, Tufail A, Chew EY, Lee CS, Fletcher EL, Bahlo M, Ansell BRE, Pébay A, Guymer RH, Lee AY, Wu Z.   +26 more
europepmc   +2 more sources

Unveiling the drivers of geographic atrophy progression in eyes with reticular pseudodrusen [PDF]

PLoS ONE
Mingui Kong, So Young Han, Sungsoon Hwang, Ga-In Lee, Je Moon Yoon, Don-Il Ham   +5 more
doaj   +2 more sources

Proposal of a Simpler Eye-Level Risk Model Incorporating Reticular Pseudodrusen for the Clinical Prediction of Late Age-Related Macular Degeneration. [PDF]

Clin Exp Ophthalmol
ABSTRACT Background The updated simplified AREDS risk model predicts progression to late age‐related macular degeneration (AMD) by person, describing up to nine observations across both eyes and 10 annual risk scores (0–4, with/without reticular pseudodrusen [RPD]).
Trinh M, Duong A, Cheung R, Chen S, Ng D, Friedrich J, Hodge C, Nivison-Smith L, Ly A.   +8 more
europepmc   +2 more sources