Results 51 to 60 of about 558,236 (245)

A Pooled CRISPR Screen Reveals Genes Critical for Erythroblast Enucleation

American Journal of Hematology, EarlyView.
ABSTRACT Terminal erythroid differentiation involves dramatic cellular remodeling that culminates in the expulsion of the nucleus, a process known as enucleation. While enucleation is conserved across mammals and is crucial for the generation of fully functional erythrocytes, the mechanisms governing this process have remained largely unknown, in part ...
Marilou Tetard, Tianjian Lin, Nana A. Peterson, Rebekah C. Gullberg, Yann Le Guen, Jasmine Moshiri, John G. Doench, Elizabeth S. Egan   +7 more
wiley   +1 more source

Red Blood Cell Surface Proteins and Cryopreservation for Tracking Altered Erythropoiesis

Drug Testing and Analysis, EarlyView.
Recombinant human erythropoietin altered red blood cell surface protein expression, but responses were inconsistent and accompanied by substantial baseline variability. Although cryopreservation reduced analytical variability, it did not improve biomarker performance, indicating limited utility for detecting altered erythropoiesis. ABSTRACT The present
Martin Thomassen, Thomas Bonne, Jonathan Graae, Sophie Møller, Ylva Hellsten, Henrik Sørensen, Nikolai B. Nordsborg, Jacob Bejder   +7 more
wiley   +1 more source

Association Analysis with LDH, Reticulocyte Counts and Hemoglobin Concentration.

, 2012
Results of SNP association analysis with other hemolytic phenotypes including hemoglobin, LDH and reticulocyte count in the CSSCD Study.
James F. Casella (167706), Marilyn J. Telen (48984), Pallav Bhatnagar (167697), Nadia Solovieff (167689), Karen Soldano (167738), Allison Ashley-Koch (73611), Christopher J. Bean (167715), Daniel A. Dworkis (167702), W. Craig Hooper (167721), Dan E. Arking (143354), Emily Barron-Casella (167710), Mark T. Gladwin (167745), Jacqueline N. Milton (167682), Elizabeth S. Klings (167759), Paola Sebastiani (32655), Stephen W. Hartley (167693), Clinton T. Baldwin (167749), Martin H. Steinberg (167753), Michael R. DeBaun (167728), Melanie E. Garrett (167734)   +19 more
core   +1 more source

Role of selenium in the pathophysiology of cardiorenal anaemia syndrome

ESC Heart Failure, Volume 12, Issue 2, Page 770-780, April 2025.
Abstract Chronic kidney disease (CKD) and cardiovascular disease (CVD) have multiple bidirectional mechanisms, and anaemia is one of the critical factors that are associated with the progression of the two disorders [referred to as cardiorenal anaemia syndrome (CRAS)].
Shigeyuki Arai, Minoru Yasukawa, Shigeru Shibata   +2 more
wiley   +1 more source

Association between human T cell leukemia virus 1 (HTLV-1) infection and advanced periodontitis in relation to hematopoietic activity among elderly participants: a cross-sectional study

Environmental Health and Preventive Medicine, 2019
Background We reported that human T cell leukemia virus 1 (HTLV-1) infection is positively associated with atherosclerosis. Recent evidence has revealed a close association of periodontitis with atherosclerosis, endothelial dysfunction, and disruption of
Yuji Shimizu, Hirotomo Yamanashi, Masayasu Kitamura, Reiko Furugen, Takahiro Iwasaki, Hideki Fukuda, Hideaki Hayashida, Koji Kawasaki, Kairi Kiyoura, Shin-Ya Kawashiri, Toshiyuki Saito, Atsushi Kawakami, Takahiro Maeda   +12 more
doaj   +1 more source

Safety and Metabolic Effects of Withania somnifera Seed Extract and Powder in Rats: Insights From DPP‐4 Molecular Docking

Food Safety and Health, EarlyView.
Withania somnifera seed extract and powder improved metabolic parameters in rats, particularly at higher extract doses, without evident hepatic, renal, hematological, or histopathological toxicity. Molecular docking further predicted strong DPP‐4 inhibitory potential of withanone, supporting the antidiabetic potential of W. somnifera seeds.
Muhammad Usman Khalid, Muhammad Waqar, Muhammad Tauseef Sultan, Muhammad Maaz, Ahmad Mujtaba Noman, Hassan Raza, Muhammad Israr, Djilali Benabdelmoumene, Abdifetah Ibrahim Omar   +8 more
wiley   +1 more source

Impact of Staining Methods and Human Factors on Accuracy of Manual Reticulocyte Enumeration

Diagnostics, 2022
Although peripheral blood reticulocyte enumeration reflects bone marrow functional integrity, which is important for differential diagnosis of hematological diseases, the factors affecting its accuracy have not been adequately addressed.
Lin-Lin Pan, Hsiu-Chen Yu, Ching-Hui Lee, Kuo-Chuan Hung, I-Ting Tsai, Cheuk-Kwan Sun   +5 more
doaj   +1 more source

A preterm neonate with infantile liver failure syndrome 1 due to leucyl‐tRNA synthetase 1 gene (LARS1) mutations with a histopathologic phenotype of neonatal hemochromatosis

JPGN Reports, EarlyView.
Abstract We report a case of a premature, growth‐restricted female infant with feeding intolerance and coagulopathy, treated initially for sepsis, who progressed to neonatal acute liver failure and end‐stage hepatic encephalopathy after a prolonged hospitalization with extensive diagnostic evaluation, and was found by autopsy to have histopathologic ...
Adrienne Bruder, Naomi Laventhal, Raja Rabah, Jacqueline Meadow   +3 more
wiley   +1 more source

Evaluation of red cell indices and manual reticulocyte parameters in iron deficiency, vitamin B12 deficiency and beta thalassemia minor patients in a tertiary care hospital [PDF]

, 2022
Background: Reticulocytes are the youngest erythrocytes released from the bone marrow. Their increase or decrease can be an indicator of erythropoietic activity or failure.
Sudhakar, Shubha, Z., Aejaz Ahamed, Upadhyaya, Krishnaraj, Shamsuddin, Shabeera, Krishnaraj Upadhyaya, Shubha Sudhakar, Aejaz Ahamed Z., Shabeera Shamsuddin   +7 more
core   +1 more source

Nudix hydrolase 15 deficiency and azathioprine toxicity in a liver transplant recipient: A case report

JPGN Reports, EarlyView.
Abstract Thiopurines, such as azathioprine (AZA), are among the immunosuppressants used to prevent allograft rejection. Thiopurines are metabolized by thiopurine S‐methyltransferase (TPMT) and nudix hydrolase 15 (NUDT15) enzymes, and their functions are highly influenced by genetic variation. We present a 6‐year‐old female with recurrent acute cellular
Jenny Q. Nguyen, Natalie Rodriguez, Kimberly A. Chapman, Matthew A. Deardorff, Keith Z. Hazleton   +4 more
wiley   +1 more source