Results 41 to 50 of about 558,236 (245)

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

Regenerative anemia identification in cats: Red blood cell indices or morphology, what to use? [PDF]

Veterinary World
Background and Aim: Anemia, a clinical condition characterized by reduced erythrocytes, is often observed in cats. Regeneration indicates that the bone marrow can respond appropriately to anemia.
Ana Catarina da Silva Teixeira Fernandes, Daniela Maria Carneiro da Silva, Felisbina Luísa Queiroga, Ana C. Silvestre-Ferreira   +3 more
doaj   +1 more source

Clinical utility of reticulocyte parameters.

, 2015
The reticulocyte count reflects the erythropoietic activity of bone marrow and is thus useful in both diagnosing anemias and monitoring bone marrow response to therapy.
Brugnara C, PLEBANI, MARIO, PIVA, ELISA, Spolaore F   +3 more
core   +1 more source

Clinical utility of hematological parameters in aplastic anemia

Scientific Reports
Hematological parameters available on automated hematology analyzers have been shown to be useful indicators for hematological disorders. However, extensive studies especially in aplastic anemia for these indices are sparse.
Lizhong Zhang, Xiaonan Han, Qiujuan Zhu, Yu Qin, Yanan Jia   +4 more
doaj   +1 more source

Performance Evaluation of Fully Automated Reticulocyte Count As A Validated Method In Comparison with Manual Count In Neonates

Pakistan Armed Forces Medical Journal
Objective: To evaluate the performance of fully automated reticulocyte count as a validated method in comparison with manual count in neonates. Study Design: cross-sectional study. Place and Duration of Study: Department of Haematology, Armed Forces
Usman Tahir Swati, Asad Mahmood, Saima Zahir, Manzar Bozdar, Sadia Ali, Tanweer Ahmed   +5 more
doaj   +1 more source

Context‐Dependent Inverse Association of Glucose–Lipid Metabolic Status With Anemia: Evidence From Multinational Multicohort Analyses

Advanced Science, EarlyView.
Across six multinational cohorts, higher triglyceride–glucose index values are consistently associated with lower prevalent and incident anemia, despite their established adverse cardiometabolic significance. This inverse relationship varies across inflammatory, cardiovascular, and renal contexts, suggesting that glucose–lipid metabolic status carries ...
Guosong Jiang, Xinxing Wang, Lianfeng Xie, Wenna Ding, Yingyong Yin, Mei Yao, Zhibo Cui, Kaiqiang Tang, Lijie Zhong, Zhi Wang, Jia Wang, Lei Lei, Xiaoxiao Qu, Chi‐E. Qiu   +13 more
wiley   +1 more source

Reticulocyte Maturation [PDF]

, 2022
Changes to the membrane proteins and rearrangement of the cytoskeleton must occur for a reticulocyte to mature into a red blood cell (RBC). Different mechanisms of reticulocyte maturation have been proposed to reduce the size and volume of the ...
Bruce, Lesley J, Stevens-Hernandez, Christian J., Christian J. Stevens-Hernandez, Lesley J. Bruce   +3 more
core   +1 more source

Effects of thyroid status on glycated hemoglobin

Indian Journal of Endocrinology and Metabolism, 2017
Introduction: Glycated hemoglobin (HbA1c) can be altered in different conditions. We hypothesize that HbA1c levels may change due to altered thyroid status, possibly due to changes in red blood cell (RBC) turnover. Objectives: The objective of this study
Rana Bhattacharjee, Anubhav Thukral, Partha Pratim Chakraborty, Ajitesh Roy, Soumik Goswami, Sujoy Ghosh, Pradip Mukhopadhyay, Satinath Mukhopadhyay, Subhankar Chowdhury   +8 more
doaj   +1 more source

Predicting Response of Severe Aplastic Anemia to Rabbit-Antithymocyte Immunoglobulin Based Immunosuppressive Therapy Combined With Eltrombopag

Frontiers in Immunology, 2022
Addition of eltrombopag (E-PAG) to intensive immunosuppressive therapy (IST) contributes to restoring hematopoiesis in patients with severe aplastic anemia (SAA).
Ruixin Li, Jiongtao Zhou, Zhengyuan Liu, Xi Chen, Qiqiang Long, Yan Yang, Shengyun Lin, Jinsong Jia, Guangsheng He, JianYong Li   +9 more
doaj   +1 more source

The Presence and Percentage of Circulating Nucleated Red Blood Cells Reveal Distinct Characteristics in Adults With Sickle Cell Disease. [PDF]

Am J Hematol
ABSTRACT Although circulating nucleated red blood cells (cNRBCs) have previously been detected in patients with sickle cell disease (SCD), their prevalence and clinical significance during steady‐state disease have not been established. We retrospectively analyzed 270 adults with an SS or Sβ0‐thalassemia genotype.
Boccadifuoco U, Lerner I, Godard A, Darnige L, Joseph L, El Nemer W, Cheminet G, Arlet JB.   +7 more
europepmc   +2 more sources