Results 131 to 140 of about 345,350 (309)

ORBIT‐AMD: Ordinal Risk, Bilateral Imaging, and Trajectory Learning for Age‐Related Macular Degeneration in Multi‐Cohorts

Advanced Science, EarlyView.
Eligibility flow and real‐world AMD burden in the UKB retinal imaging cohort and TMUEH external‐validation cohort. Overview of the ORBIT‐AMD architecture, integrating retinal representation pretraining, bilateral eye‐graph modeling and concept bottleneck learning to support ordered risk, bilateral context, interpretable lesion concepts, longitudinal ...
Xuehao Cui, Dejia Wen, Patrick Yu‐Wai‐Man, Xiaorong Li   +3 more
wiley   +1 more source

Magnitude of Visual Acuity Change with ETDRS versus Snellen Testing in Clinical Trials

Ophthalmology Science
Purpose: To compare visual acuity (VA) changes using standardized ETDRS best-corrected visual acuity (BCVA) and nonstandardized Snellen VA among subjects enrolled in clinical trials. Design: Retrospective study.
Mirataollah Salabati, MD, Charles Huang, BS, Alireza Kamalipour, MD, Hannah J. Yu, BS, Raziyeh Mahmoudzadeh, MD, Karen Jeng-Miller, MD, MPH, Eric Chen, MD, Chirag P. Shah, MD, MPH, Charles C. Wykoff, MD, PhD, Jason Hsu, MD   +9 more
doaj   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

Contribution of Na(v) channels to the development and function of the retina

, 2017
Voltage gated (Nav) channel isoforms are precisely located in the nervous system and expressed sequentially during development. Because Nav channels control the rising phase of action potentials isoform differences may play a fundamental role in neural ...
Smith, Benjamin
core  

Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7

Advanced Science, EarlyView.
Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Yunkyung Kim, Gaeun Lee, Saemin An, Hanseul Park, Hongwon Kim, Jisung Kim, Soi Kang, Sumin Kim, Daeyeol Kwon, Jeonghyun Park, Yerim Hwang, Seonghun Kim, Xiuwen Yuan, Jaehoon Jeong, Hamin Lee, Hui Kwon Kim, Jongpil Kim   +16 more
wiley   +1 more source

Pasta, a Versatile Transcriptomic Clock, Maps the Chemical and Genetic Determinants of Aging and Rejuvenation

Advanced Science, EarlyView.
Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon, Maria Tsiokou, Patricia Marqués, Enriqueta Rodríguez‐Diaz, Hazel Ang, Federico Pietrocola, Christian G. Riedel   +6 more
wiley   +1 more source

Concussion of the Retina [PDF]

BMJ, 1900
openaire   +2 more sources

An Aggregation‐Induced Polymerization Poly(Disulfide)‐Drug Nanoplatform for Autoimmune Uveitis Therapy via Inhibiting the cGAS‐STING Pathway

Advanced Science, EarlyView.
A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu, Wenbo Geng, Qinjin Dai, Wanyun Zhang, Yuxian Lai, Pei Zhang, Chunjiang Zhou, Yinuo Wang, Qingfeng Cao, Xiang Luo, Yujie Lai, Changwei Huang, Peizeng Yang   +12 more
wiley   +1 more source

Relationship Between Serous Retinal Detachment And Serum Glycosylated Hemoglobin Levels İn Diabetic Macular Edema

, 2016
Amaç: Diyabetik maküla ödemi (DMÖ) olan hastalarda seröz maküla dekolmanı (SMD) sıklığını ve glikolize hemoglobin (HbA1c) ile ilişkisini araştırmak.
Burçin Köklü, Sibel Alişan, Gürsoy Alagöz, Emine Doğan, Erkan Çelik, Alagöz, Gürsoy, Şule Coşkun, Sakarya Üniversitesi, Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Sakarya Üniversitesi, Eğitim ve Araştırma Hastanesi, Göz Hastalıkları Kliniği   +8 more
core   +1 more source

İdiyopatik Makula Deliklerinin Tedavisinde İndosiyanin Yeşili Yardımı ile Retina İç Limitan Membranın Soyulması

, 2005
Amaç: İdiyopatik makula deliklerinin tedavisinde indosiyanin yeşili (İSY) ile boyanarak retina iç limitan membranın (İLM) soyulmasının anatomik ve görsel sonuçlara etkisini araştırmak. Gereç ve Yöntem: İdiyopatik makula deliği olan ardışık 26 hastanın 26
Avci, Remzi, Yildiz, Meral, Şimşek, Şaban, Kaderli, Berkant   +3 more
core