Results 181 to 190 of about 664,556 (407)

Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications

open access: yesAdvanced Science, EarlyView.
HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang   +5 more
wiley   +1 more source

Verteporfin‐Mediated In Situ Nanovaccine Based on Local Conventional‐Dose Hypofractionated Radiotherapy Enhances Antitumor and Immunomodulatory Effect

open access: yesAdvanced Science, EarlyView.
Here gelatinase‐responsive methoxypolyethyleneglycol–PVGLIG–polycaprolactone (mPEG–PVGLIG–PCL) nanoparticles’ loading verteporfin (N@VP) is developed, enhancing radiotherapy via X‐ray‐triggered singlet oxygen generation. Combined with 2 Gy (gray, a radiation dose unit) irradiation, N@VP achieves antitumor efficacy comparable to 8 Gy, and also promotes ...
Zhifan Zhang   +16 more
wiley   +1 more source

Detailed Visual Cortical Responses Generated by Retinal Sheet Transplants in Rats with Severe Retinal Degeneration. [PDF]

open access: yes, 2018
To combat retinal degeneration, healthy fetal retinal sheets have been successfully transplanted into both rodent models and humans, with synaptic connectivity between transplant and degenerated host retina having been confirmed.
Aramant, Robert B   +7 more
core  

Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues

open access: yesAdvanced Science, EarlyView.
Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang   +4 more
wiley   +1 more source

The function of photomechanical movements in the retina of the rainbow trout (Salmo gairdneri) [PDF]

open access: yes, 1982
1. The function of photomechanical movements in the retina of rainbow trout (Salmo gairdneri) was investigated by determining both the effect of light on the level of extractable visual pigment, and the electroretinographic b-wave sensitivity, during ...
Douglas, R. H.
core  

A Transition Metal‐Free Approach for the Conversion of Real‐Life Cellulose‐Based Biomass into Formate

open access: yesAdvanced Science, EarlyView.
A visible‐light‐mediated method has been developed for the direct conversion of biomass into formate at ambient temperature and atmospheric pressure. This approach achieves the selective generation of hydroxyl radicals, which subsequently transform sugars, cellulose, and hemicellulose into formate.
Tong Zhang   +7 more
wiley   +1 more source

Expanding the clinical spectrum associated with the PACS1 p.Arg203Trp mutational hot‐spot: Two additional Italian patients

open access: yes, 2023
American Journal of Medical Genetics Part A, Volume 191, Issue 1, Page 284-288, January 2023.
Lucia Pia Bruno   +11 more
wiley   +1 more source

The elusive scleral cartilages: Comparative anatomy and development in teleosts and avians

open access: yesThe Anatomical Record, EarlyView., 2023
Abstract The sclera of all vertebrate eyes is comprised of connective tissue, with some organisms developing cartilage within this tissue. A review of the cartilages that have been described in the vertebrate sclera and their anatomical relationships is discussed together with their potential homology.
Tamara A. Franz‐Odendaal
wiley   +1 more source

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