Results 61 to 70 of about 448,808 (241)

Leveraging Design of Experiments to Unravel the Amplification Mechanism of Single‐Molecule Wide‐Field Biosensors

open access: yesAdvanced Materials Interfaces, EarlyView.
Detecting single molecules on large interfaces is challenging due to minimal perturbations on the sensing surface. Some biological systems achieve this feat using amplification mechanisms, but their molecular foundations remain unclear. To investigate, a Design of Experiments (DoE) approach examines how pH and ionic strength in conditioning solutions ...
Michele Catacchio   +9 more
wiley   +1 more source

The retina [PDF]

open access: yesCurrent Biology, 1999
Neves, Guilherme, Lagnado, Leon
openaire   +2 more sources

Multimodal Platforms for Light‐Mediated Organic Bioelectronics

open access: yesAdvanced Materials Interfaces, EarlyView.
Optobioelectronic devices are paving the way for different types of interfacing with cells, in addition to classical electrical interfacing. Here, a future perspective for research in this field is discussed, in which different classes of light‐responsive materials are combined to create a highly dynamic interface that truly integrates with biological ...
Giovanna Gentile   +4 more
wiley   +1 more source

Targeted Local Delivery via Fiber‐Embedded Flexible Microchannels Integrated with Film‐Based Implantable Probes

open access: yesAdvanced Materials Technologies, EarlyView.
In this study, a fiber‐embedded drug delivery channel for implantable microprobes, demonstrating the first functional drug delivery system using flexible LCP‐based probes, is developed. The design incorporates fibers for site‐selective drug delivery and electrical functions. The utilization of monolithic thermal bonding simplifies fabrication.
Jaehwan Byun   +6 more
wiley   +1 more source

Photoactive Monolayer MoS2 for Spiking Neural Networks Enabled Machine Vision Applications

open access: yesAdvanced Materials Technologies, EarlyView.
Molybdenum disulfide (MoS2) optoelectronic devices are implemented as Leaky Integrate‐and‐Fire (LIF) neurons in spiking neural networks (SNNs), where light‐induced photocurrent dynamics represent potentiation (τd) and depression (τd), emulating neuronal membrane potential.
Thiha Aung   +5 more
wiley   +1 more source

A minimal statistical-mechanical model for multihyperuniform patterns in avian retina

open access: yes, 2020
Birds are known for their extremely acute sense of vision. The very peculiar structural distribution of five different types of cones in the retina underlies this exquisite ability to sample light.
Guisández, Leandro   +3 more
core   +2 more sources

Xenopus NM23-X4 regulates retinal gliogenesis through interaction with p27Xic1 [PDF]

open access: yes, 2009
Background. In Xenopus retinogenesis, p27Xic1, a Xenopus cyclin dependent kinase inhibitor, functions as a cell fate determinant in both gliogenesis and neurogenesis in a context dependent manner.
Aikaterini Bilitou   +6 more
core   +3 more sources

Emerging Therapeutic Strategies for Hearing Loss

open access: yesAdvanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han   +9 more
wiley   +1 more source

Immune Checkpoint PD‐L1 Modulates Retinal Microglial Activation to Alleviate Vascular Leakage in Choroidal Neovascularization via ERK

open access: yesAdvanced Science, EarlyView.
PD‐L1 limits neuroinflammation in neovascular AMD by modulating microglial activation. Its deficiency exacerbates vascular leakage and choroidal neovascularization (CNV) via ERK signaling, while enhancing PD‐L1 reduces inflammation and neovascularization. Targeting PD‐L1 may offer a novel immunomodulatory strategy for NVAMD.
Yue Zou   +7 more
wiley   +1 more source

Detachment of the Retina [PDF]

open access: yesThe American Journal of the Medical Sciences, 1896
n ...
openaire   +1 more source

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