Results 41 to 50 of about 522,726 (295)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

In vivo laser Doppler holography of the human retina

, 2018
The eye offers a unique opportunity for non-invasive exploration of cardiovascular diseases. Optical angiography in the retina requires sensitive measurements, which hinders conventional full-field laser Doppler imaging schemes.
Atlan, M., Fink, M., Paques, M., Puyo, L., Sahel, J. -A.   +4 more
core   +1 more source

Early CRT monitoring using time-domain optical coherence tomography does not add to visual acuity for predicting visual loss in patients with central retinal vein occlusion treated with intravitreal ranibizumab:A secondary analysis of trial data [PDF]

, 2017
Our primary purpose was to assess the clinical (predictive) validity of central retinal thickness (CRT) and best corrected visual acuity (BCVA) at 1 week and 1 month after starting treatment with ranibizumab for central retinal vein occlusion.
Bell, Katy J L, Duerr, Hans Peter, Farris, Maria, Glasziou, Paul, Hayen, Andrew, Irwig, Les, Mitchell, Andrew S., Mitchell, Paul, Wright, Jonathan   +8 more
core   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dorsoventral patterning of the Xenopus eye involves differential temporal changes in the response of optic stalk and retinal progenitors to Hh signalling [PDF]

, 2015
Background: Hedgehog (Hh) signals are instrumental to the dorsoventral patterning of the vertebrate eye, promoting optic stalk and ventral retinal fates and repressing dorsal retinal identity.
G., Barsacchi, Lupo, Giuseppe, R., He, W. A., Harris, X., Wang, Y., Liu   +5 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Methylene blue associated retinal toxicity

International Journal of Retina and Vitreous
Background To describe a case of inadvertent methylene blue use during pars plana vitrectomy (PPV) for an epiretinal membrane (ERM). Case A 69-year-old man presented with 1 day of severe vision loss in his left eye. Two days prior to presentation, he had
Sidra Zafar, Martin Calotti, Timothy T. Xu, Justin Muste, Theodore Bowe, Luis Acaba-Berrocal, Brian Cheng, Samir N. Patel, Yoshihiro Yonekawa, Jose S. Pulido, Jordan D. Deaner   +10 more
doaj   +1 more source

Automatic optometer operates with infrared test pattern [PDF]

, 1970
Refractive strength of human eye is monitored by optometer that automatically and continuously images infrared test pattern onto the retina. Condition of focus of the eye at any instant is determined from optometer settings needed to maintain focus of ...
Cornsweet, T. N., Crane, H. D.
core   +1 more source

Irregular S-cone mosaics in felid retinas: spatial interaction with axonless horizontal revealed by cross-correlation [PDF]

, 2000
In most mammals short-wavelength-sensitive (S) cones are arranged in irregular patterns with widely variable intercell distances. Consequently, mosaics of connected interneurons either may show some type of correlation to photoreceptor placement or may ...
Ahnelt, Ahnelt, Ahnelt, Ahnelt, Ahnelt, Anna Kübber-Heiss, Boycott, Chan, Chiu, Clark, Cook, Curcio, Curcio, Dacey, de Monasterio, Eduardo Fernández, Famiglietti, Fernández, Gallego, Galli-Resta, Green, Hack, Hendrickson, Hokoç, Johnson, Jose Angel Bolea, Kolb, Kouyama, Long, Luo, Martin, Mills, Müller, Oscar Martinez, Peter Kurt Ahnelt, Pflug, Provencio, Raviola, Rodieck, Rodieck, Sandmann, Shapiro, Soni, Sun, Szél, Szél, Szél, Wikler, Williams, Williams, Wässle, Wässle, Wässle   +52 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source