Results 141 to 150 of about 1,135,598 (287)

Pigment Epithelium‐Derived Factor Deficiency Impairs Hippocampal Glutamate Homeostasis and Cognitive Function by Downregulating Astrocytic GLT‐1

Advanced Science, EarlyView.
The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi, Qi‐Long Tang, Jin‐Hong Wang, Yan‐Lan Long, Sai‐Feng Zhao, Zhen Zhao, Wan‐Ting Xie, Zi‐Ming Li, Hao‐Ming Lu, Tian‐Xiao Gao, Zhen‐Zhen Fang, Ti Zhou, Bo‐Xing Li, Xia Yang, Guo‐Quan Gao, Wei‐Wei Qi   +15 more
wiley   +1 more source

Correction: High-fat diet-induced dyslipidemia drives retinal ECE-1 and ET-1 upregulation [PDF]

Shuo Sun, Huilan Zhang, Jing Chen, Kaiwen Hei, Yi Hou, Yanhui Yang, Chunyan Shan, Longli Zhang   +7 more
openalex   +1 more source

Glucocorticoids exert differential effects on the endothelium in an in vitro model of the blood–retinal barrier [PDF]

, 2018
Anne‐Eva van der Wijk, Paul Canning, Rutger P. van Heijningen, Ilse M. C. Vogels, Cornelis J.F. Van Noorden, Ingeborg Klaassen, Reinier O. Schlingemann   +6 more
openalex   +1 more source

The Effect of Intra-arterial Thrombolysis in Retinal Artery Occlusion: Case Series and Literature Review [PDF]

, 2020
Sang Il Cho, J. Kim, Nam Chun Cho
openalex   +1 more source

Single‐Cell RNA Sequencing of Retina Reveals Nna1 Upregulation in Myopic Diabetic Retinopathy as a Protective Factor Against Diabetic Damage

Advanced Science, EarlyView.
This study investigates a schematic overview of the mechanistic pathways. The relationship between myopia and DR has long been of clinical interest. In diabetic mice, Nna1 expression is downregulated, whereas in diabetic mice with FDM, Nna1 expression is upregulated–particularly in Müller cells–accompanied by decreased vascular endothelial growth ...
Lihui Xie, Yingjun Cai, Bolin Chen, Bowen Li, Jing Zou, Huizhuo Xu   +5 more
wiley   +1 more source

NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex

Advanced Science, EarlyView.
The primary neurological manifestations of tuberous sclerosis complex (TSC) are intractable epilepsy and intellectual disability. NEAT1 is differentially expressed in TSC‐related epilepsy and influences neuronal excitability by regulating the PI3K/AKT/mTOR signaling pathway.
Suhui Kuang, Tinghong Liu, Zhirong Wei, Jinshan Xu, Jiayi Han, Jiaqi Wang, Feng Zhai, Yiran Tian, Shuli Liang   +8 more
wiley   +1 more source

Continuous Suppression of Pathological Retinal and Choroidal Neovascularization in Cynomolgus Monkeys via Noninvasive Ophthalmic Delivery of a Novel Anti‐VEGFA Nanobody and Proprietary Penetratin Analog Formulation

Advanced Science, EarlyView.
Pathological retinal/choroidal neovascularization drives vision loss in DR and AMD. Current anti‐VEGF injections, while effective, require invasive, frequent administration. Pene/LQ015, is developed a novel topical anti‐VEGFA nanobody formulation achieving therapeutic intraocular levels through penetratin analog‐enhanced delivery.
Chong Chen, Min Zhu, Xingyan Fan, Kangjia Lv, Kuan Jiang, Yuchen Zhang, Haoliang Zhang, Xinming Qi, Benjamin TK Lee, Yakun Wan, Gang Wei, Kun Liu, Xun Xu   +12 more
wiley   +1 more source

Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus

Proceedings of the National Academy of Sciences of the United States of America, 2016
E. Sohn, Hille W van Dijk, C. Jiao, P. Kok, Woojin Jeong, N. Demirkaya, Allison Garmager, F. Wit, M. Kucukevcilioglu, M. V. van Velthoven, J. DeVries, R. Mullins, M. Kuehn, R. Schlingemann, M. Sonka, F. Verbraak, M. Abràmoff   +16 more
semanticscholar   +1 more source

Intrinsic Photo‐Crosslinkable Semiconductive Small‐Molecule Crystals (i‐PSSCs) for Patterning Electronic Devices

Advanced Science, EarlyView.
A novel intrinsic photo‐crosslinkable semiconductive small molecule is designed and synthesized. The solution‐processed crystalline film can be patterned by in situ photopolymerization under UV light irradiation without external crosslinking agents, and the crystalline order and charge transport properties are preserved, demonstrating potential for ...
Huaqing Li, Xiaoguang Hu, Lei Zhang, Qingqing Sun, Chuan Liu, Linlin Zhang, Takeo Minari, Xuying Liu   +7 more
wiley   +1 more source

Investigating the Role of Zebrafish Retinoschisin Homologs Rs1a and Rs1b During Retinal Development. [PDF]

Dev Neurobiol
van der Veen I, Koster C, Brink JBT, Kamermans M, Boon CJF.   +4 more
europepmc   +1 more source