Results 71 to 80 of about 339,258 (186)

Detailed Visual Cortical Responses Generated by Retinal Sheet Transplants in Rats with Severe Retinal Degeneration. [PDF]

, 2018
To combat retinal degeneration, healthy fetal retinal sheets have been successfully transplanted into both rodent models and humans, with synaptic connectivity between transplant and degenerated host retina having been confirmed.
Aramant, Robert B, Foik, Andrzej T, Lean, Georgina A, Lyon, David C, Mathur, Anuradha, McLelland, Bryce T, Scholl, Leo R, Seiler, Magdalene J   +7 more
core  

Chromatin remodeling protein HELLS is critical for retinoblastoma tumor initiation and progression. [PDF]

, 2020
Retinoblastoma is an aggressive childhood cancer of the developing retina that initiates by biallelic RB1 gene inactivation. Tumor progression in retinoblastoma is driven by epigenetics, as retinoblastoma genomes are stable, but the mechanism(s) that ...
Benavente, Claudia A, Gu, Yijun, Mehta, Aditi, Spitale, Robert C, Suh, Susie, Wang, Jingtian, Wu, Jie, Wu, Stephanie C, Zocchi, Loredana   +8 more
core  

Multimodal Platforms for Light‐Mediated Organic Bioelectronics

Advanced Materials Interfaces, EarlyView.
Optobioelectronic devices are paving the way for different types of interfacing with cells, in addition to classical electrical interfacing. Here, a future perspective for research in this field is discussed, in which different classes of light‐responsive materials are combined to create a highly dynamic interface that truly integrates with biological ...
Giovanna Gentile, Mehdi Ravandeh, Luisa Petti, Francesca D'Elia, Francesca Santoro   +4 more
wiley   +1 more source

Targeted Local Delivery via Fiber‐Embedded Flexible Microchannels Integrated with Film‐Based Implantable Probes

Advanced Materials Technologies, EarlyView.
In this study, a fiber‐embedded drug delivery channel for implantable microprobes, demonstrating the first functional drug delivery system using flexible LCP‐based probes, is developed. The design incorporates fibers for site‐selective drug delivery and electrical functions. The utilization of monolithic thermal bonding simplifies fabrication.
Jaehwan Byun, Jungseub Lee, Hyun Ryul Ryu, Geun Jae Lee, Sung Eun Lee, Sung June Kim, Noo Li Jeon   +6 more
wiley   +1 more source

Photoactive Monolayer MoS2 for Spiking Neural Networks Enabled Machine Vision Applications

Advanced Materials Technologies, EarlyView.
Molybdenum disulfide (MoS2) optoelectronic devices are implemented as Leaky Integrate‐and‐Fire (LIF) neurons in spiking neural networks (SNNs), where light‐induced photocurrent dynamics represent potentiation (τd) and depression (τd), emulating neuronal membrane potential.
Thiha Aung, Sindhu Priya Giridhar, Irfan H. Abidi, Taimur Ahmed, Akram AI‐Hourani, Sumeet Walia   +5 more
wiley   +1 more source

Vascular changes in diabetic retinopathy-a longitudinal study in the Nile rat. [PDF]

, 2019
Diabetic retinopathy is the most common microvascular complication of diabetes and is a major cause of blindness, but an understanding of the pathogenesis of the disease has been hampered by a lack of accurate animal models. Here, we explore the dynamics
Blodi, Barbara A, Bozadjian, Rachel V, Clegg, Dennis O, Coffey, Peter J, Keeley, Patrick W, Lockwood, Madison D, Reese, Benjamin E, Sadjadi, Ryan, Smolentsev, Alexander, Thomson, James A, Toh, Huishi   +10 more
core  

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, EarlyView.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

Immune Checkpoint PD‐L1 Modulates Retinal Microglial Activation to Alleviate Vascular Leakage in Choroidal Neovascularization via ERK

Advanced Science, EarlyView.
PD‐L1 limits neuroinflammation in neovascular AMD by modulating microglial activation. Its deficiency exacerbates vascular leakage and choroidal neovascularization (CNV) via ERK signaling, while enhancing PD‐L1 reduces inflammation and neovascularization. Targeting PD‐L1 may offer a novel immunomodulatory strategy for NVAMD.
Yue Zou, Junliang Jiang, Yunqin Li, Xinyi Ding, Qiuping Tong, Ying Shi, Lei Xiao, Ling Chen   +7 more
wiley   +1 more source

Lycium barbarum Glycopeptide Alleviates Neomycin‐Induced Ototoxicity by Inhibiting Tryptophan Hydroxylase‐Mediated Serotonin Biosynthesis

Advanced Science, EarlyView.
Lycium barbarum glycopeptide (LBGP), which is further extracted from Lycium barbarum polysaccharides, exhibits significant protective effects against neomycin‐induced hearing dysfunction including oxidative stress in cochlea and loss of key cells in cochlea.
Yunhao Wu, Li Zhang, Shengda Cao, Jingwen Zhang, Cheng Li, Yunlong Shan, Qiuping Liu, Zhexiong Yu, Qiaojun Fang, Yuhua Zhang, Xiaolong Fu, Kwok‐Fai So, Renjie Chai   +12 more
wiley   +1 more source

Retinal photodamage

Journal of Photochemistry and Photobiology B: Biology, 2001
The retina represents a paradox, in that, while light and oxygen are essential for vision, these conditions also favour the formation of reactive oxygen species leading to photochemical damage to the retina. Such light damage seems to be multi-factorial and is dependent on the photoreactivity of a variety of chromophores (e.g., vitamin A metabolites ...
Boulton, Mike, Różanowska, Małgorzata, Różanowski, Bartosz   +2 more
openaire   +3 more sources