Results 51 to 60 of about 499,083 (318)

Molecular Properties of β-Carotene Oxygenases and Their Potential in Industrial Production of Vitamin A and Its Derivatives

Antioxidants, 2022
β-Carotene 15,15′-oxygenase (BCO1) and β-carotene 9′,10′-oxygenase (BCO2) are potential producers of vitamin A derivatives, since they can catalyze the oxidative cleavage of dietary provitamin A carotenoids to retinoids and derivative such as ...
Kyung-Chul Shin, Min-Ju Seo, Yeong-Su Kim, Soo-Jin Yeom   +3 more
doaj   +1 more source

Astrocyte-derived vascular endothelial growth factor stabilizes vessels in the developing retinal vasculature [PDF]

, 2010
Vascular endothelial growth factor (VEGF) plays a critical role in normal development as well as retinal vasculature disease. During retinal vascularization, VEGF is most strongly expressed by not yet vascularized retinal astrocytes, but also by retinal ...
Michael B. Powner, Powner, MB, Scott, A., Clarkin, C., Gandhi, P, Scott, Andrew, David H Gutmann, Randall S Johnson, Fruttiger, Marcus, Gutmann, DH, Johnson, RS, David H. Gutmann, Gutmann David H., Gutmann, David H., Powner Michael B., Gandhi, P., Scott Andrew, Clarkin Claire, Ferrara, N., Gandhi Pranita, Napoleone Ferrara, Johnson Randall S., Clarkin, Claire, Scott, A, Pranita Gandhi, Ferrara, Napoleone, Michael B Powner, Fruttiger Marcus, Gandhi, Pranita, Powner, Michael B., Ferrara Napoleone, Andrew Scott, Powner, M. B., Connon, Che John, Ferrara, N, Claire Clarkin, Clarkin, C, Fruttiger, M., Johnson, R.S., Gutmann, D.H., Fruttiger, M, Randall S. Johnson, Johnson, Randall S., Marcus Fruttiger   +43 more
core   +1 more source

Biosynthesis of retinoic acid by intestinal enzymes of the rat

Journal of Lipid Research, 1967
The incubation of Β-carotene-14C with the soluble fraction of the intestinal mucosa resulted in the formation of small amounts of acidic material. The addition of NAD or NADH to the soluble fraction caused a tenfold increase in this material.
F.D. Crain, F.J. Lotspeich, R.F. Krause
doaj   +1 more source

Retinal remodeling in human retinitis pigmentosa

Experimental Eye Research, 2016
Retinitis Pigmentosa (RP) in the human is a progressive, currently irreversible neural degenerative disease usually caused by gene defects that disrupt the function or architecture of the photoreceptors. While RP can initially be a disease of photoreceptors, there is increasing evidence that the inner retina becomes progressively disorganized as the ...
Jones, B.W., Pfeiffer, R.L., Ferrell, W.D., Watt, C.B., Marmor, M., Marc, R.E.   +5 more
openaire   +2 more sources

Long-term visual and microperimetry outcomes following autologous retinal pigment epithelium choroid graft for neovascular age-related macular degeneration

, 2009
To describe the 2- to 4-year visual and microperimetry outcomes of autologous retinal pigment epithelium (RPE)-choroid graft in patients with neovascular age-related macular degeneration (AMD).In this retrospective cohort study, 12 patients with ...
Coffey, PJ, Uppal, GS, Rubin, GS, Chen, FK, Tufail, A, Maclaren, Robert, Franzco, FKC, Aylward, GW, Da Cruz, L, MacLaren, RE   +9 more
core   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Retinal imaging in inherited retinal diseases

Annals of Eye Science, 2020
Inherited retinal diseases (IRD) are a leading cause of blindness in the working age population. The advances in ocular genetics, retinal imaging and molecular biology, have conspired to create the ideal environment for establishing treatments for IRD, with the first approved gene therapy and the commencement of multiple therapy trials.
Georgiou, Michalis, Fujinami, Kaoru, Michaelides, Michel   +2 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Multifocal ocular haemorrhages secondary to COVID-19-related immune thrombocytopenia—Report of a rare case

TNOA Journal of Ophthalmic Science and Research
We report a rare case of subconjunctival, optic nerve head and retinal haemorrhages secondary to immune thrombocytopenia (ITP) associated with coronavirus disease 2019 (COVID-19).
K Divya, A Raghuram, S Padmanaban, Sujaya Menon   +3 more
doaj   +1 more source

Retinal Vessel Extraction with the Image Ray Transform [PDF]

, 2010
Extraction of blood vessels within the retina is an important task that can help in detecting a number of diseases, including diabetic retinopathy. Current techniques achieve good, but not perfect performance and this suggests that improved preprocessing
Mark S. Nixon, Nixon, Mark, Cummings, Alastair, Alastair H. Cummings   +3 more
core   +1 more source