Microbial Rhodopsins: Structural–Functional Mechanisms and the Design of Optogenetic Silencing Tools—With Emphasis on Halorubrum Archaeorhodopsins [PDF]
BiologyMicrobial rhodopsins are light-sensitive membrane proteins that use retinal as a covalent chromophore and adopt a seven-transmembrane α-helical fold. They are widely distributed across archaea, bacteria, algae, and fungi and mediate diverse functions ...
Luomeng Chao, Yuxia Yang
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Molecular properties of a viral heliorhodopsin, V2HeR2 [PDF]
Biophysics and PhysicobiologyHeliorhodopsin (HeR) is a family of microbial rhodopsin discovered in 2018, whose genes are found from archaea, bacteria, unicellular eukaryotes, and giant viruses.
Ritsu Mizutori +5 more
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A second photoactivatable state of the anion-conducting channelrhodopsin GtACR1 empowers persistent activity [PDF]
Communications BiologyOptogenetics is a method to regulate cells, tissues and organisms using light. It is applied to study neurons and to develop diagnostic and therapeutic tools for neuron-related diseases.
Kristin Labudda +7 more
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Structural basis for the prolonged photocycle of sensory rhodopsin II revealed by serial synchrotron crystallography [PDF]
Nature CommunicationsMicrobial rhodopsins form a diverse family of light-sensitive seven-transmembrane helix retinal proteins that function as active proton or ion pumps, passive light-gated ion channels, and photosensors.
Robert Bosman +13 more
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Frontiers in Molecular Biosciences, 2022 Microbial rhodopsins have recently been discovered in pathogenic fungi and have been postulated to be involved in signaling during the course of an infection.
Mariafrancesca La Greca +7 more
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Factors that control the chemistry of the LOV domain photocycle. [PDF]
PLoS ONE, 2014 Algae, plants, bacteria and fungi contain Light-Oxygen-Voltage (LOV) domains that function as blue light sensors to control cellular responses to light. All LOV domains contain a bound flavin chromophore that is reduced upon photon absorption and forms a
Josiah P Zayner, Tobin R Sosnick
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Imaging Voltage with Microbial Rhodopsins
Frontiers in Molecular Biosciences, 2021 Membrane potential is the critical parameter that reflects the excitability of a neuron, and it is usually measured by electrophysiological recordings with electrodes.
Xiao Min Zhang +3 more
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Microsecond All-Optical Modulation by Biofunctionalized Porous Silicon Microcavity
Nanomaterials, 2023 We successfully created a composite photonic structure out of porous silicon (PSi) microcavities doped by the photochromic protein, photoactive yellow protein (PYP).
Dániel Petrovszki +7 more
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Role of Thr82 for the unique photochemistry of TAT rhodopsin
Biophysics and Physicobiology, 2021 Marine bacterial TAT rhodopsin possesses the pKa of the retinal Schiff base, the chromophore, at neutral pH, and photoexcitation of the visible protonated state forms the isomerized 13-cis state, but reverts to the original state within 10–5 sec.
Teppei Sugimoto +2 more
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Near-Infrared Activation of Sensory Rhodopsin II Mediated by NIR-to-Blue Upconversion Nanoparticles
Frontiers in Molecular Biosciences, 2022 Direct optical activation of microbial rhodopsins in deep biological tissue suffers from ineffective light delivery because visible light is strongly scattered and absorbed.
Momo Yaguchi +5 more
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