Results 41 to 50 of about 719,139 (306)

Use of ocular biomarkers as a potential tool for early diagnosis of Alzheimer's disease

Indian Journal of Ophthalmology, 2020
Alzheimer's disease (AD) is the most common neurodegenerative disease worldwide which unfortunately has no known effective cure to date. Despite many clinical trials indicating the effectiveness of preclinical treatment, a sensitive tool for screening of
Ajay K Singh, Shilpa Verma
doaj   +1 more source

The effects of growth factors on multicellular spheroids formed by chick embryonic retinal cells [PDF]

, 1997
Retinal cells from chick embryos aged 7.5 days of gestation were cultured for two months in a non-adherent suspension culture dish to study the effects of growth factors and co-culture with retinal pigment epithelial cells on their differentiation ...
Matsuo, Nobuhiko, Matsuo, Toshihiko, Takabatake, Mayumi   +2 more
core   +1 more source

Biosynthesis of retinoic acid by intestinal enzymes of the rat

Journal of Lipid Research, 1967
The incubation of Β-carotene-14C with the soluble fraction of the intestinal mucosa resulted in the formation of small amounts of acidic material. The addition of NAD or NADH to the soluble fraction caused a tenfold increase in this material.
F.D. Crain, F.J. Lotspeich, R.F. Krause
doaj   +1 more source

Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids [PDF]

, 2019
Tissue specific extracellular matrices (ECM) provide structural support and enable access to molecular signals and metabolites, which are essential for directing stem cell renewal and differentiation.
Al-Aama, Jumana, Asfour, Hani Z., Ding, Yuchun, Doherty, Mary, Dorgau, Birthe, Felemban, Majed, Hallam, Dean, Hilgen, Gerrit, Hunt, Nicola Claire, Kiening, Martin, Krasnogor, Natalio, Lako, Majlinda, Sernagor, Evelyne, White, Kathryn, Whitfield, Phil, Zerti, Darin   +15 more
core   +2 more sources

Multimodal Retinal Imaging for Detection of Ischemic Stroke

Frontiers in Aging Neuroscience, 2021
Background: This study aims to evaluate ocular changes in patients with ischemic stroke using multimodal imaging and explore the predictive value of ocular abnormalities for ischemic stroke.Methods: A total of 203 patients (ischemic stroke group, 62 ...
Lu Zhao, Hui Wang, Xiufen Yang, Bin Jiang, Hongyang Li, Hongyang Li, Yanling Wang   +6 more
doaj   +1 more source

A Smartphone-Based Tool for Rapid, Portable, and Automated Wide-Field Retinal Imaging. [PDF]

, 2018
Purpose:High-quality, wide-field retinal imaging is a valuable method for screening preventable, vision-threatening diseases of the retina. Smartphone-based retinal cameras hold promise for increasing access to retinal imaging, but variable image quality
Davila, Jose R, Echanique, Chris, Fletcher, Daniel A, Keenan, Jeremy, Kim, Tyson N, Li, Patrick, Loumou, Panagiota, Loury, PJ, Maamari, Robi N, Margolis, Todd, Myers, Frank, Paulus, Yannis M, Reber, Clay, Switz, Neil A, Webster, Doug, Woodward, Maria A   +15 more
core  

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul, Jatuporn Sujjitjoon, Pa‐thai Yenchitsomanus, Kridtin Jarutatsanangkoon, Ng Wei Loon, Kleebsabai Sanpakit, Jassada Buaboonnam, Chayamon Takpradit, Pornpimon Yuti, Nunghathai Sawasdee, Piriya Luangwattananun, Siripakorn Sangkitporn, Arnan Limmahachai, La‐ongsri Atchaneeyasakul   +13 more
wiley   +1 more source

Retinal micro-vascular and aortic macro-vascular changes in postmenopausal women with primary hyperparathyroidism [PDF]

, 2018
Aim of the study was to evaluate the micro and macro-vascular changes in patients with primary hyperparathyroidism (PHPT) compared to controls. 30 postmenopausal PHPT women (15 hypertensive and 15 normotensive) and 30 normotensive controls underwent ...
Biamonte, Federica, Cipriani, Cristiana, Colangelo, Luciano, Curione, Mario, Minisola, Salvatore, Parravano, Mariacristina, Pepe, Jessica, Tedeschi, Massimiliano, Varano, Monica   +8 more
core   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Multifocal ocular haemorrhages secondary to COVID-19-related immune thrombocytopenia—Report of a rare case

TNOA Journal of Ophthalmic Science and Research
We report a rare case of subconjunctival, optic nerve head and retinal haemorrhages secondary to immune thrombocytopenia (ITP) associated with coronavirus disease 2019 (COVID-19).
K Divya, A Raghuram, S Padmanaban, Sujaya Menon   +3 more
doaj   +1 more source