Results 111 to 120 of about 33,197 (253)

Minocycline and bone marrow–derived mononuclear cells as potential therapeutics for hereditary retinal degenerations

Acta Ophthalmologica, EarlyView.
Abstract Purpose To assess in Royal College of Surgeons (RCS) rats if the combination of two previously documented neuroprotective strategies: minocycline administration and bone marrow–derived mononuclear cells (BM‐MNCs) intravitreal transplantation, offers enhanced neuroprotection compared with each treatment alone.
Alba Videla‐Ristol, Ana Martínez‐Vacas, David García‐Bernal, Manuel Vidal‐Sanz, María Paz Villegas‐Pérez, Diego García‐Ayuso, Johnny Di Pierdomenico   +6 more
wiley   +1 more source

Retinal Phenotype in the rd9 Mutant Mouse, a Model of X-Linked RP

Frontiers in Neuroscience, 2019
Retinal degeneration 9 (rd9) mice carry a mutation in the retina specific “Retinitis Pigmentosa GTPase Regulator (RPGR)” Open Reading Frame (ORF) 15 gene, located on the X chromosome and represent a rare model of X-linked Retinitis Pigmentosa (XLRP), a ...
Antonio Falasconi, Antonio Falasconi, Martina Biagioni, Elena Novelli, Ilaria Piano, Claudia Gargini, Enrica Strettoi   +6 more
doaj   +1 more source

Microfluidic processing of stem cells for autologous cell replacement

Stem Cells Translational Medicine, 2021
Autologous photoreceptor cell replacement is one of the most promising approaches currently under development for the treatment of inherited retinal degenerative blindness.
Nicholas E. Stone, Andrew P. Voigt, Robert F. Mullins, Todd Sulchek, Budd A. Tucker   +4 more
doaj   +1 more source

Duration‐Dependent Efficacy and Clinical Safety of Repeated Low‐Level Red‐Light Therapy for Paediatric Myopia: A Systematic Review and Meta‐Analysis

Clinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Background Repeated low‐level red‐light (RLRL) therapy is a novel, non‐invasive intervention for controlling paediatric myopia progression. Despite increasing clinical use, questions remain regarding the magnitude, durability, and safety of treatment effects.
Lee‐Yuan Lin, Cheng‐Hao Hsu, Hung Su, Jia‐Wei Sun, Jie‐Syuan Wu, Wei‐Jung Jeng, Chen‐Hsin Tsai, Fara Silvia Yuliani, Shyh‐Hsiang Lin   +8 more
wiley   +1 more source

Additional file 1 of cGMP-grade human iPSC-derived retinal photoreceptor precursor cells rescue cone photoreceptor damage in non-human primates

, 2021
Additional file 1: Table S1: List of primary antibodies used in the study. figure S1: Estimation of GFP expression by FACS. After lentivirus infection, 95% of the RPC cells expressed GFP (left panel). There was no GFP in the non-infection control (right panel). figure S2: Controls for GFP, SC121 and AMA staining.
Lingam, Swathi, Liu, Zengping, Yang, Binxia, Wong, Wendy, Parikh, Bhav Harshad, Ong, Jun Yi, Goh, Debbie, Wong, Daniel Soo Lin, Tan, Queenie Shu Woon, Tan, Gavin S. W., Holder, Graham E., Regha, Kakkad, Barathi, Veluchamy Amutha, Hunziker, Walter, Lingam, Gopal, Zeng, Xianmin, Su, Xinyi   +16 more
openaire   +1 more source

Transplanted Donor- or Stem Cell-Derived Cone Photoreceptors Can Both Integrate and Undergo Material Transfer in an Environment-Dependent Manner

Stem Cell Reports, 2018
Summary: Human vision relies heavily upon cone photoreceptors, and their loss results in permanent visual impairment. Transplantation of healthy photoreceptors can restore visual function in models of inherited blindness, a process previously understood ...
Paul V. Waldron, Fabiana Di Marco, Kamil Kruczek, Joana Ribeiro, Anna B. Graca, Claire Hippert, Nozie D. Aghaizu, Aikaterini A. Kalargyrou, Amanda C. Barber, Giulia Grimaldi, Yanai Duran, Samuel J.I. Blackford, Magdalena Kloc, Debbie Goh, Eduardo Zabala Aldunate, Robert D. Sampson, James W.B. Bainbridge, Alexander J. Smith, Anai Gonzalez-Cordero, Jane C. Sowden, Robin R. Ali, Rachael A. Pearson   +21 more
doaj   +1 more source

Structural diversity of neuronal calcium sensor proteins and insights for activation of retinal guanylyl cyclase by GCAP1. [PDF]

, 2014
Neuronal calcium sensor (NCS) proteins, a sub-branch of the calmodulin superfamily, are expressed in the brain and retina where they transduce calcium signals and are genetically linked to degenerative diseases.
Ames, James B, Dizhoor, Alexander M, Lim, Sunghyuk   +2 more
core   +2 more sources

Next‐Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS

Cell Proliferation, EarlyView.
Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang, Jinrui Li, Xingjia Mao, Wanyu Wang, Yansong Li, Xuefei Hu, Jinjie Zhong, Fengdong Zhao, Linlin Wang   +8 more
wiley   +1 more source

Evolution of the eyes of vipers with and without infrared-sensing pit organs [PDF]

, 2019
We examined lens and brille transmittance, photoreceptors, visual pigments, and visual opsin gene sequences of viperid snakes with and without infrared-sensing pit organs. Ocular media transmittance is high in both groups.
Douglas, R. H., Gower, D. J., Grace, M. S., Hart, N. S., Hunt, D. M., Loew, E. R., McLamb, W., Orlov, N., Partridge, J. C., Peichl, L., Sampaio, F. L., Simoes, B. F., Wagner, H. J.   +12 more
core   +3 more sources

A supramolecular assembly of cone‐specific G‐protein and cryptochrome 4a on lipid bilayer

The FEBS Journal, EarlyView.
Immobilized phospholipid bilayers on a sensor chip surface serve as membrane platform to investigate critical protein–lipid and protein–protein interaction processes by surface plasmon resonance. The putative magnetoreceptor cryptochrome 4a and the myristoylated cone‐specific G‐protein α‐subunit (Gtα) bind with high affinity to immobilized lipid ...
Ümmügülsüm Güzelsoy‐Flügge, Srđan Vujinović, Alexander Scholten, Karl‐Wilhelm Koch   +3 more
wiley   +1 more source