Results 151 to 160 of about 33,197 (253)

Rod photoreceptors drive circadian photoentrainment across a wide range of light intensities. [PDF]

, 2010
In mammals, synchronization of the circadian pacemaker in the hypothalamus is achieved through direct input from the eyes conveyed by intrinsically photosensitive retinal ganglion cells (ipRGCs).
Alam, Nazia M, Altimus, Cara M, Arman, A Cyrus, Güler, Ali D, Hattar, Samer, Prusky, Glen T, Sampath, Alapakkam P   +6 more
core  

Decellularized Aged Bruch's Membrane Confers Unique Biochemical Cues to Retinal Pigment Epithelium for In Vitro Modeling of Age‐Related Macular Degeneration

Aging Cell, Volume 25, Issue 5, May 2026.
A Bruchs membrane (BrM) mimic based on aged decellularized BrM was developed and differentially expressed proteins in aged dECM‐BrM that may provide specific biochemical cues fundamental to model AMD in vitro were identified. RPE culture on aged dECM‐BrM developed certain AMD‐like features including reduced TEER and expression of drusen components ...
Blanca Molins, Mercedes Soledad Nabaes Jodar, Eliandre de Oliveira, Josep Maria Estanyol, Esther Peña, Jaione Bezunartea, María Hernández, Marc Figueras‐Roca, Alfredo Adan   +8 more
wiley   +1 more source

Exploring ocular fundus morphology in relation to growth in adolescents born moderate‐to‐late preterm

Acta Ophthalmologica, Volume 104, Issue 3, Page e346-e355, May 2026.
Abstract Purpose To study ocular fundus morphology and its relation to growth in adolescents born moderate‐to‐late preterm (MLP) and full term. Methods This prospective and population‐based cohort study included 50 MLP adolescents (26 girls, mean age 16.5 years) and 50 full‐term controls (30 girls, mean age 16.7 years).
Alexandra Lind, Sara Ali, Titus Ovik, Zoran Popovic, Eva Aring, Jovanna Dahlgren, Marita Andersson Grönlund   +6 more
wiley   +1 more source

Advances in the genetics of refractive errors: Contributions from the CREAM consortium

Acta Ophthalmologica, Volume 104, Issue 3, Page e222-e231, May 2026.
Abstract The Consortium for Refractive Error and Myopia (CREAM) was established in 2011, bringing together an international team of researchers studying more than 30 cohorts. Since its establishment, CREAM has played a pivotal role in research investigating the genetics of myopia and other refractive errors, serving as a key driver of progress in the ...
Sze Wai Rosa Li, Xi He, Louise Terry, Virginie J. M. Verhoeven, Samantha Sze‐Yee Lee, Gareth Lingham, Jeremy A. Guggenheim, David A. Mackey, Seang‐Mei Saw, Caroline C. W. Klaver, Chi Pui Pang, CREAM Consortium   +11 more
wiley   +1 more source

CERKL gene knockout disturbs photoreceptor outer segment phagocytosis and causes rod-cone dystrophy in zebrafish [PDF]

, 2017
Biswas, Lincoln, Han, Shanshan, Hu, Xuebin, Huang, Yuwen, Jiang, Tao, Li, Chang, Liu, Fei, Liu, Jing Yu, Liu, Mugen, Liu, Xiliang, Liu, Ying, Lu, Zhaojing, Reilly, James, Shu, Xinhua, Tang, Zhaohui, Wang, Lei, Wong, Fulton, Yu, Shanshan   +17 more
core   +1 more source

Retinal Pigment Epitheliopathy due to Sub‐Optimal Recycling of Vitamin A (RESORVA): A Novel RDH11 ‐Related Phenotype

Clinical Genetics, Volume 109, Issue 5, Page 972-977, May 2026.
RDH11 is a minor isoenzyme that catalyses the oxidation of 11‐cis‐retinol to 11‐cis‐retinal in the retinal pigment epithelium, alongside RDH5 and RDH10. Biallelic null variants in RDH11 lead to upregulation of RDH5 and RDH10 (transcriptional adaptation), maintaining 11‐cis‐retinal bioavailability, but still causing Retinal Pigment Epitheliopathy due to
Kirk A. J. Stephenson, Zhuo Shao, Anupreet Tumber, Erika Tavares, Kashif Ahmed, Edward J. Higginbotham, Christian R. Marshall, Jason T. Maynes, Ammaji Rajala, Raju V. S. Rajala, Elise Héon, Ajoy Vincent   +11 more
wiley   +1 more source

Quantum Dots‐caused Retinal Degeneration in Zebrafish Regulated by Ferroptosis and Mitophagy in Retinal Pigment Epithelial Cells through Inhibiting Spliceosome

Advanced Science
Quantum dots (QDs) are widely used, but their health impact on the visual system is little known. This study aims to elucidate the effects and mechanisms of typical metallic QDs on retinas using zebrafish.
Naying Zheng, Tingting Liao, Chuchu Zhang, Zheyang Zhang, Sen Yan, Xiaohan Xi, Fengkai Ruan, Chunyan Yang, Qingliang Zhao, Wenbo Deng, Jialiang Huang, Zi‐Tao Huang, Zhi‐Feng Chen, Xiang Wang, Qingming Qu, Zhenghong Zuo, Chengyong He   +16 more
doaj   +1 more source

Establishing a Zebrafish Functional Assay to Assess the Pathogenicity of Variants of Uncertain Significance in Ciliopathies

European Journal of Clinical Investigation, Volume 56, Issue 5, May 2026.
A zebrafish morpholino knockdown model targeting ahi1 enables efficient phenotypic assessment of ciliopathy‐related defects and functional evaluation of variants of uncertain significance. This assay clarifies the impact of VUSs, supporting zebrafish morphants as a reliable platform for validating ciliopathy‐associated genetic variants.
Carla Aresi, Francesca Tonelli, Concetta Mazzotta, Valentina Serpieri, Cecilia Masiero, Camilla Torriani, Simona Villani, Enza Maria Valente, Antonella Forlino   +8 more
wiley   +1 more source

Knockout of Nr2e3 prevents rod photoreceptor differentiation and leads to selective L-/M-cone photoreceptor degeneration in zebrafish [PDF]

, 2019
Han, Shanshan, Hu, Xuebin, Huang, Yuwen, Jiang, Tao, Li, Jingzhen, Liu, Fei, Liu, Mugen, Liu, Xiliang, Lv, Yuexia, Qin, Yayun, Qu, Zhen, Reilly, James, Shu, Xinhua, Tang, Zhaohui, Tu, Jiayi, Xie, Shanglun, Yimer, Tinsae Assefa, Yu, Shanshan   +17 more
core   +1 more source

Repeatability of \u3cem\u3eIn Vivo\u3c/em\u3e Parafoveal Cone Density and Spacing Measurements [PDF]

, 2012
Purpose. To assess the repeatability and measurement error associated with cone density and nearest neighbor distance (NND) estimates in images of the parafoveal cone mosaic obtained with an adaptive optics scanning light ophthalmoscope (AOSLO).Methods ...
Carroll, Joseph, Cooper, Robert F., Dubis, Adam M., Dubra, Alfredo, Garrioch, Robert, Langlo, Christopher S.   +5 more
core   +1 more source