Results 101 to 110 of about 640,739 (357)
SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy
Advanced Science, EarlyView.During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong +9 more
wiley +1 more source
Neuroprotection, Growth Factors and BDNF-TrkB Signalling in Retinal Degeneration
International Journal of Molecular Sciences, 2016 Neurotrophic factors play key roles in the development and survival of neurons. The potent neuroprotective effects of neurotrophic factors, including brain-derived neurotrophic factor (BDNF), ciliary neurotrophic factor (CNTF), glial cell-line derived ...
A. Kimura +4 more
semanticscholar +1 more source
Advanced Science, EarlyView.Iron‐induced lipid peroxidation of phosphatidylethanolamine (PE) species is the key driver of ferroptosis. The authors discovered that PHOSPHO1 lowers the level of PE in retinal pigment epithelial cells thus reducing the formation of lipid peroxides. Lowering PE levels can also prevent the creation of autolysosomes, reduce the production of free iron ...
Zhiyang Chen +19 more
wiley +1 more source
Progression of transsynaptic retinal degeneration with spectral-domain optical coherence tomography
American Journal of Ophthalmology Case Reports, 2017 Purpose: To illustrate the progression of retrograde transsynaptic retinal degeneration using spectral-domain optical coherence tomography (SD-OCT). Observations: A 60 year-old man with a stroke was followed over a 17-month period using SD-OCT of the ...
Stephen G. Schwartz +2 more
doaj +1 more source
Stimulation of AMPK prevents degeneration of photoreceptors and the retinal pigment epithelium
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance In this paper, we show that stimulation of adenosine monophosphate-activated protein kinase (AMPK) by metformin is able to protect photoreceptors and the retinal pigmented epithelium (RPE) in three different mouse models of retinal ...
Lei Xu, Li Kong, Jian-gang Wang, J. Ash
semanticscholar +1 more source
Advanced Intelligent Systems, EarlyView.This study introduces a data augmentation method that expands an ophthalmology dataset by 12x, enhancing robustness and reducing overfitting. A novel VNet architecture improves accuracy by 10% over the original dataset and 5% over Grand Challenge benchmarks.
Samad Azimi Abriz +3 more
wiley +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Recessive Stargardt macular degeneration (STGD1) and a subset of cone–rod dystrophies are caused by mutations in the Abca4 gene. The ABCA4 protein is a flippase in photoreceptor cells that helps eliminate retinaldehyde, a toxic photoproduct ...
T. Lenis +14 more
semanticscholar +1 more source
Costello Syndrome and Ophthalmologic Issues: Unveiling the Unseen
American Journal of Medical Genetics Part A, Volume 197, Issue 7, July 2025.ABSTRACT Costello syndrome (CS) is an ultra‐rare condition belonging to the RASopathies, a group of disorders characterized by aberrant RAS/MAPK pathway signaling, which is involved in ocular development and in some eye pathologies. However, only a few studies assessing the ophthalmic features of individuals with CS are available.
Sofia Peschiaroli +13 more
wiley +1 more source
Needle detection and localisation for robot‐assisted subretinal injection using deep learning
CAAI Transactions on Intelligence Technology, EarlyView., 2023 Abstract Subretinal injection is a complicated task for retinal surgeons to operate manually. In this paper we demonstrate a robust framework for needle detection and localisation in robot‐assisted subretinal injection using microscope‐integrated Optical Coherence Tomography with deep learning.
Mingchuan Zhou +9 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.The present study investigates the role of the NLRP3 inflammasome in the chronicity of ocular inflammation in uveitis using the experimental autoimmune uveitis (EAU) model. Whole eyes collected from EAU mice, 12 weeks post induction, were sectioned and subjected to immunohistochemistry. The confocal images from these sections were then assessed for the
Avik Shome +3 more
wiley +1 more source