Results 101 to 110 of about 110,459 (310)

Potential neuroprotective and therapeutic agents and their mechanisms for irradiation‐induced brain injury

Ibrain, EarlyView.
In this review, agents such baicalein, troxerutin, epigallocatechin gallate, quercetin, melatonin, valproic acid, lithium, neurosteroid progesterone, as well as minocycline have been implicated as neuroprotective agents for irradiation‐induced neurological deficits. Also, agents such as glucocorticoids, methylphenidate, vitamin E, bisdemethoxycurcumin,
Seidu A. Richard, Vivian Kapio Abem, Sagor Kumar Roy   +2 more
wiley   +1 more source

Retinal pigment epithelium-specific CLIC4 mutant is a mouse model of dry age-related macular degeneration [PDF]

, 2022
Jen-Zen Chuang, Nan Yang, Nobuyuki Nakajima, Wataru Otsu, Cheng Fu, Howard H. Yang, Maxwell P. Lee, Armaan F. Akbar, Tudor C. Badea, Ziqi Guo, Afnan Nuruzzaman, Kuo‐Shun Hsu, Joshua L. Dunaief, Ching‐Hwa Sung   +13 more
openalex   +1 more source

Hypertensive retinopathy in pre‐eclampsia and its association with disease severity and neonatal outcomes: A retrospective cohort study

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Introduction Pre‐eclampsia (PE) involves systemic endothelial dysfunction and microvascular injury, yet routine obstetric care lacks noninvasive readouts of maternal microvascular health. We evaluated whether hypertensive retinopathy (HR) detected during pregnancy is associated with maternal disease severity and adverse neonatal outcomes ...
Gabriele Saccone, Francesco Matarazzo, Mariarosaria Motta, Marika Rovetto, Michele Rinaldi, Maurizio Guida, Ciro Costagliola   +6 more
wiley   +1 more source

Non‐invasive and efficient diabetic retinal mitochondrial repair nanoplatform based on engineered endothelial mitochondrial‐derived vesicles with dynamic integrated stress response modulation

Interdisciplinary Medicine, EarlyView.
Under hyperglycemic conditions, mitochondrial dysfunction in retinal endothelial cells triggers excessive reactive oxygen species/reactive nitrogen species production, barrier protein degradation, and endothelial barrier breakdown in diabetic retinopathy.
Siyu Gui, Jie Gao, Tianchang Tao, Peng Wang, Zhihao Huang, Yuyang She, Jiajie Li, Jingwan Su, Zhe Lu, Jianchao Qiao, Song Wang, Xiaodong Sun, Mohan Li   +12 more
wiley   +1 more source

Ginsenoside Rb1 Targets the HRD1‐STING Axis to Mitigate Cholesterol‐Induced VSMC Senescence

Journal of Clinical Laboratory Analysis, EarlyView.
Schematic representation of the proposed mechanism of action for Ginsenoside Rb1. Suppression of HRD1 expression in VSMCs cholesterol stimulation, leading to ER stress (BiP/XBP1s upregulation), STING pathway activation, ROS accumulation (including mitochondrial ROS), and ultimately, VSMC senescence.
Haiming Niu, Yingzhang Cai, Conghui Yu, Ning Lin, Miaolian Chen, Linli Wang   +5 more
wiley   +1 more source

Voluntary exercise preserves visual function and reduces inflammatory response in an adult mouse model of autosomal dominant retinitis pigmentosa

Scientific Reports
Whole-body physical exercise has been shown to promote retinal structure and function preservation in animal models of retinal degeneration. It is currently unknown how exercise modulates retinal inflammatory responses.
Katie L. Bales, Austin M. Karesh, Kelleigh Hogan, Alicia S. Chacko, GianMarco L. Douglas, Andrew J. Feola, John M. Nickerson, Alyssa Pybus, Levi Wood, Jeffrey H. Boatright, Machelle T. Pardue   +10 more
doaj   +1 more source

Efficacy of omega‐3 fatty acids as a functional food: a multifaceted approach to health reinforcement

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Omega‐3 fatty acids (omega‐3s) are polyunsaturated fatty acids linked with numerous health benefits. Omega‐3s exhibit multifaceted activities through various mechanisms. Eicosapentaenoic acid (EPA) alleviates oxidative stress by lowering reactive oxygen species and improving oxidative stress in brain tissues and acts against neurodegenerative ...
Md Faruque Ahmad, Abdulrahman A Alsayegh, Anjum Khanam, Awais Ahmed, António Raposo, Farkad Bantun, Md Zeyaullah, Ahmad O Babalghith, Abdullah F Aldairi, Boshra Mozaffar, Mohammed F Bajahzer, Mohamed H Abdelrahman, Mohammad Intakhab Alam   +12 more
wiley   +1 more source

Dynamic Retinal Pathology in Glaucoma Progression Revealed by High‐Resolution Functional Imaging in Vivo

Laser &Photonics Reviews, EarlyView.
In this work, we investigated the dynamic retinal pathology of glaucoma from onset to late stages through longitudinal in vivo high‐resolution imaging in a silicone oil‐induced ocular hypertension (SOHU) glaucoma mouse model. We developed an optimized adaptive optics two‐photon excitation fluorescence microscopy (AO‐TPEFM) technique for morphological ...
Yiming Fu, Pham Binh Minh, Sicong He, Yingzhu He, Zhongya Qin, Ting Xie, Jianan Qu   +6 more
wiley   +1 more source

Ex Vivo Evaluation of Poly(Solketal Acrylate) Nanoparticles for Intravitreal Drug Delivery to the Posterior Eye Segment

Macromolecular Rapid Communications, EarlyView.
Nile Red‐loaded poly(solketal acrylate) nanoparticles enable fluorescence tracking and exhibit nontoxic profiles in retinal cells. Enhanced cellular uptake and deep retinal penetration after intravitreal injection highlight their excellent potential for targeted ocular drug delivery to the posterior segment of the eye.
Yasaman Pourdakheli Hamedani, José Hurst, Malte Ritter, Philipp Weingarten, Julia Skokowa, Sven Schnichels, Friederike Adams   +6 more
wiley   +1 more source

Deep Learning for Retinal Degeneration Assessment: A Comprehensive Analysis of the MARIO Challenge [PDF]

Rachid Zeghlache, Ikram Brahim, Pierre-Henri Conze, Mathieu Lamard, Mohammed El Amine Lazouni, Zineb Aziza Elaouaber, Leila Ryma Lazouni, Christopher Sivert Nielsen, Amimul Ahsan, Matthias Wilms, Nils D. Forkert, Lovre Antonio Budimir, Ivana Zadro Matovinovic, Donik Vršnak, Sven Lončarić, Philippe Zhang, Weili Jiang, Yihao Li, Yiding Hao, Markus Frohmann, Perry S. Binder, Marcel Huber, Taha Emre, Teresa Araújo, Marzieh Oghbaie, Hrvoje Bogunović, Amerens A. Bekkers, Nina M. van Liebergen, Hugo J. Kuijf, Abdul Qayyum, Moona Mazher, Steven Niederer, Alberto J. Beltrán-Carrero, Juan J. Gómez-Valverde, Javier Torresano-Rodríquez, Álvaro Caballero-Sastre, María J. Ledesma‐Carbayo, Yosuke Yamagishi, Yi Ding, Robin Peretzke, Alexandra Ertl, Maximilian Fischer, Jessica Kächele, Sofiane Zehar, Karim Boukli Hacene, Thomas Monfort, Béatrice Cochener, Mostafa El Habib Daho, Anas‐Alexis Benyoussef, Gwenolé Quellec   +49 more
openalex   +1 more source